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Substance Name: Bosutinib [USAN:INN]
RN: 380843-75-4
UNII: 5018V4AEZ0
InChIKey: UBPYILGKFZZVDX-UHFFFAOYSA-N

Notes

  • A 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases.
  • A 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases.

    NCI: A drug used to treat chronic myelogenous leukemia (CML). It is used in patients who cannot be treated with or have not gotten better with other treatment. It is also being studied in the treatment of other types of cancer. Bosutinib blocks the action of BCR-ABL and other proteins, which may help keep cancer cells from growing and may kill cancer cells. It is a type of tyrosine kinase inhibitor. Also called Bosulif.

Molecular Formula

  • C26-H29-Cl2-N5-O3

Molecular Weight

  • 530.4531
 

Classification Codes

  • Antineoplastic (Src Kinase Inhibitor)
  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Bosutinib [USAN:INN]

Synonyms

  • Bosulif
  • Bosutinib
  • EC 700-455-1
  • SKI 606
  • SKI-606
  • SKI606
  • UNII-5018V4AEZ0

Systematic Names

  • 3-Quinolinecarbonitrile, 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-
  • 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile
  • 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

Registry Numbers

CAS Registry Number

  • 380843-75-4

FDA UNII

  • 5018V4AEZ0

System Generated Number

  • 0380843754

Structure Descriptors

InChI

1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChIKey

UBPYILGKFZZVDX-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)CCCOc2cc3c(cc2OC)c(c(cn3)C#N)Nc4cc(c(cc4Cl)Cl)OC