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Substance Name: Piperacetazine [USAN:USP:INN]
RN: 3819-00-9
UNII: KL6248WNW4
InChIKey: BTFMCMVEUCGQDX-UHFFFAOYSA-N

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H30-N2-O2-S

Molecular Weight

  • 410.579
 
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Names and Synonyms

Name of Substance

  • Piperacetazine
  • Piperacetazine [USAN:USP:INN]

Synonyms

  • 10-(3-(4-(2-Hydroxyethyl)piperidino)propyl)phenothiazin-2-yl methyl ketone
  • 2-Acetyl-10-(3-(4-(beta-hydroxyethyl)piperidino)propyl)phenothiazine
  • EINECS 223-312-0
  • Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperidinyl)propyl)-10H-phenothiazin-2-yl)-
  • PC-1421
  • Piperacetazina
  • Piperacetazina [INN-Spanish]
  • Piperacetazine
  • Piperacetazinum
  • Piperacetazinum [INN-Latin]
  • Piperazetazina
  • Piperazetazina [DCIT]
  • Psymod
  • Quide
  • SC 9794
  • UNII-KL6248WNW4

Systematic Names

  • 1-(10-(3-(4-(2-Hydroxyethyl)-1-piperidinyl)propyl)-10H-phenothiazin-2-yl)ethanone
  • Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperidinyl)propyl)-10H-phenothiazin-2-yl)-
  • Ketone, 10-(3-(4-(2-hydroxyethyl)piperidino)propyl)phenothiazin-2-yl methyl
  • Piperacetazine

Registry Numbers

CAS Registry Number

  • 3819-00-9

FDA UNII

  • KL6248WNW4

System Generated Number

  • 0003819009

Structure Descriptors

InChI

1S/C24H30N2O2S/c1-18(28)20-7-8-24-22(17-20)26(21-5-2-3-6-23(21)29-24)13-4-12-25-14-9-19(10-15-25)11-16-27/h2-3,5-8,17,19,27H,4,9-16H2,1H3

InChIKey

BTFMCMVEUCGQDX-UHFFFAOYSA-N

Smiles

CC(=O)c1ccc2c(c1)N(c3ccccc3S2)CCCN4CCC(CC4)CCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 5, Pg. 49, 1963.
dog LD50 intraperitoneal 100mg/kg (100mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 39, 1972.
dog LDLo intravenous 32mg/kg (32mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 5, Pg. 49, 1963.
mouse LD50 intraperitoneal 98mg/kg (98mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 152, 1962.
mouse LD50 oral 575mg/kg (575mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 152, 1962.
mouse LD50 subcutaneous 365mg/kg (365mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 374, 1964.
rat LD50 intraperitoneal 93mg/kg (93mg/kg)   Toxicology and Applied Pharmacology. Vol. 5, Pg. 49, 1963.
rat LD50 oral 390mg/kg (390mg/kg)   Toxicology and Applied Pharmacology. Vol. 5, Pg. 49, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.050 (none)   EST
Atmospheric OH Rate Constant 2.50E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.