Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Minoxidil [USAN:USP:INN:BAN]
RN: 38304-91-5
UNII: 5965120SH1
InChIKey: ZFMITUMMTDLWHR-UHFFFAOYSA-N

Note

  • A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)

Molecular Formula

  • C9-H15-N5-O

Molecular Weight

  • 209.2515
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Hair Growth Stimulant (Topical)
  • Human Data
  • Reproductive Effect
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Minoxidil
  • Minoxidil [USAN:USP:INN:BAN]

MeSH Heading

  • Minoxidil

Synonyms

  • 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
  • 2,4-Diamino-6-piperidinilpirimidina-3-ossido
  • 2,4-Diamino-6-piperidinilpirimidina-3-ossido [Italian]
  • 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide
  • 2,4-Diamino-6-piperidinopyrimidine 3-oxide
  • 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
  • 2,6-Diamino-4-piperidinopyrimidin-1-oxid
  • 5-25-12-00317 (Beilstein Handbook Reference)
  • 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
  • 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
  • 6-Piperidino-2,4-diaminopyrimidine 3-oxide
  • Alopexil
  • Alostil
  • BRN 0886240
  • EINECS 253-874-2
  • HSDB 6538
  • Loniten
  • Lonolox
  • Men's Rogaine
  • Minodyl
  • Minossidile
  • Minossidile [Italian]
  • Minoxidil
  • Minoxidil (for men)
  • Minoxidil (for women)
  • Minoxidil extra strength (for men)
  • Minoxidilum
  • Minoxidilum [INN-Latin]
  • Minoximen
  • Mintop
  • Normoxidil
  • PDP
  • Pierminox
  • Prexidil
  • Regaine
  • RiUP
  • Rogaine
  • Rogaine (for men)
  • Rogaine (for women)
  • Rogaine extra strength (for men)
  • Theroxidil
  • Tricoxidil
  • U 10858
  • U-10,858
  • UNII-5965120SH1
  • Women's Rogaine

Systematic Names

  • 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
  • Minoxidil
  • Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide

Mixture Name

  • Men's Rogaine Foam

Registry Numbers

CAS Registry Number

  • 38304-91-5

FDA UNII

  • 5965120SH1

Other Registry Number

  • 16317-69-4

System Generated Number

  • 0038304915

Structure Descriptors

InChI

1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12)

InChIKey

ZFMITUMMTDLWHR-UHFFFAOYSA-N

Smiles

c1c(n(=O)c(nc1N2CCCCC2)N)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 69mg/kg/34W-I (69mg/kg) CARDIAC: PERICARDITIS

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Western Journal of Medicine. Vol. 143, Pg. 527, 1985.
man TDLo oral 107ug/kg/3D-I (0.107mg/kg) BLOOD: THROMBOCYTOPENIA Annals of Internal Medicine. Vol. 92, Pg. 874, 1980.
mouse LD50 intraperitoneal 560mg/kg (560mg/kg)   Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982.
mouse LD50 intravenous 51mg/kg (51mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982.
rat LD50 intraperitoneal 759mg/kg (759mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
rat LD50 intravenous 49mg/kg (49mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
rat LD50 oral 1321mg/kg (1321mg/kg)   Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
women TDLo oral 200ug/kg (0.2mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Archives of Internal Medicine. Vol. 146, Pg. 2075, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 248 deg C   EXP
pKa Dissociation Constant 4.61 (none)   EXP
log P (octanol-water) 1.24 (none)   EXP
Water Solubility 2200 mg/L   EXP
Vapor Pressure 1.03E-07 mm Hg 25 EST
Henry's Law Constant 2.12E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.26E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.