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Substance Name: Moperone hydrochloride [JAN]
RN: 3871-82-7
UNII: 2Z2633815T
InChIKey: RJTOSFZZYBCYTM-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H26-F-N-O2.Cl-H

Molecular Weight

  • 391.9113
 
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Names and Synonyms

Name of Substance

  • Moperone hydrochloride
  • Moperone hydrochloride [JAN]

Synonyms

  • 4'-Fluoro-4-(4-hydroxy-4-p-tolylpiperidino)butyrophenone, hydrochloride
  • 4-(p-Tolyl)-1-(3'-(p-fluorobenzoyl)propyl)-piperidinol-(4) hydrochloride
  • EINECS 223-392-7
  • Luvatren
  • Luvatrena
  • Meldol
  • Methylperidol HCl
  • Methylperidol hydrochloride
  • Moperone chlorohydrate
  • Moperone HCl
  • Moperone hydrochloride
  • Moperonum hydrochloride
  • NSC 170974
  • R 1658
  • UNII-2Z2633815T

Systematic Names

  • 1-(3-(p-Fluorobenzoyl)propyl)-4-hydroxy-4-(p-tolyl)piperidinium chloride
  • 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(4-methylphenyl)-1-piperidinyl)-, hydrochloride (9CI)
  • Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-p-tolylpiperidino)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 3871-82-7

FDA UNII

  • 2Z2633815T

Related Registry Number

  • 1050-79-9 (Parent)

System Generated Number

  • 0003871827

Molecular Formulas

Molecular Formula

  • C22-H26-F-N-O2.Cl-H

Molecular Formula Fragments

  • C22-H26-F-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H26FNO2.ClH/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18;/h4-11,26H,2-3,12-16H2,1H3;1H

InChIKey

RJTOSFZZYBCYTM-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)C2(CC[NH+](CC2)CCCC(=O)c3ccc(cc3)F)O.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 15500ug/kg (15.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 869, 1970.
mouse LD50 oral 218mg/kg (218mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 869, 1970.
mouse LD50 subcutaneous 28100ug/kg (28.1mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 869, 1970.
rat LD50 intravenous 12100ug/kg (12.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 869, 1970.
rat LD50 oral 152mg/kg (152mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 869, 1970.
rat LD50 subcutaneous 24500ug/kg (24.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 869, 1970.