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Substance Name: Triptolide
RN: 38748-32-2
UNII: 19ALD1S53J
InChIKey: DFBIRQPKNDILPW-CIVMWXNOSA-N

Note

  • Also has antiangiogenic, anti-inflammatory, and neuroprotective activities; a phytogenic antineoplastic agent; a tri-epoxide phenanthrene from Chinese herb, Tripterygium wilfordii.

Molecular Formula

  • C20-H24-O6

Molecular Weight

  • 360.4036
 

Classification Codes

  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Antispermatogenic Agents
  • Contraceptive Agents
  • Contraceptive Agents, Male
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Immunosuppressive Agents
  • Natural Product
  • Noxae
  • Reproductive Control Agents
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Names and Synonyms

Name of Substance

  • Triptolide

Synonyms

  • NSC 163062
  • Triptolid
  • Triptolide
  • UNII-19ALD1S53J

Systematic Names

  • Triptolide (9CI)
  • Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

Registry Numbers

CAS Registry Number

  • 38748-32-2

FDA UNII

  • 19ALD1S53J

System Generated Number

  • 0038748322

Structure Descriptors

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChIKey

DFBIRQPKNDILPW-CIVMWXNOSA-N

Smiles

CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 900ug/kg (0.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 2, Pg. 70, 1981.
mouse LD50 intravenous 800ug/kg (0.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 2, Pg. 70, 1981.