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Substance Name: Tandutinib [USAN:INN]
RN: 387867-13-2
UNII: E1IO3ICJ9A
InChIKey: UXXQOJXBIDBUAC-UHFFFAOYSA-N

Notes

  • Inhibits platelet-derived growth factor receptor tyrosine kinase.
  • MeSH: Inhibits platelet-derived growth factor receptor tyrosine kinase.

    NCI: A substance being studied in the treatment of some types of cancer. It may stop cancer cell growth by blocking certain enzymes. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Also called CT53518 and MLN518.

Molecular Formula

  • C31-H42-N6-O4

Molecular Weight

  • 562.7108
 

Classification Code

  • Treatment of Cardiovascular Diseases, Fibrotic Diseases and Acute Myelogenous Leukemia (Tyrosine Kinase Inhibitor)
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Names and Synonyms

Name of Substance

  • Tandutinib
  • Tandutinib [USAN:INN]

Synonyms

  • (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
  • 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-
  • 4-(6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)-N-(4-(1-methylethoxy)phenyl)piperazine-1-carboxamide
  • CT 53518
  • CT53518
  • MLN 518
  • Tandutinib
  • UNII-E1IO3ICJ9A

Systematic Name

  • 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-

Registry Numbers

CAS Registry Number

  • 387867-13-2

FDA UNII

  • E1IO3ICJ9A

System Generated Number

  • 0387867132

Structure Descriptors

InChI

1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)

InChIKey

UXXQOJXBIDBUAC-UHFFFAOYSA-N

Smiles

CC(C)Oc1ccc(cc1)NC(=O)N2CCN(CC2)c3c4cc(c(cc4ncn3)OCCCN5CCCCC5)OC