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Substance Name: Indoramin hydrochloride [USAN:BAN]
RN: 38821-52-2
UNII: DQ0Z3K8W92
InChIKey: AFJSFHAKSSWOKG-UHFFFAOYSA-N

Note

  • A hypotensive agent with some anti-arrhythmic effects.

Molecular Formula

  • C22-H25-N3-O.Cl-H

Molecular Weight

  • 383.9204
 

Classification Codes

  • Adrenergic Antagonists
  • Antihypertensive
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Indoramin hydrochloride [USAN:BAN]

Synonyms

  • Baratol
  • Baratol (pharmaceutical)
  • Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-, monohydrochloride
  • EINECS 254-136-2
  • Indoramin HCl
  • Indoramin hydrochloride
  • N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide hydrochloride
  • N-(1-(2-Indol-3-ylethyl)-4-piperidyl)benzamide monohydrochloride
  • UNII-DQ0Z3K8W92
  • WY 21901
  • WY-21,901 HCl

Systematic Names

  • Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-, monohydrochloride
  • N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidyl)benzamide monohydrochloride

Registry Numbers

CAS Registry Number

  • 38821-52-2

FDA UNII

  • DQ0Z3K8W92

Other Registry Number

  • 33124-53-7

System Generated Number

  • 0038821522

Molecular Formulas

Molecular Formula

  • C22-H25-N3-O.Cl-H

Molecular Formula Fragments

  • C22-H25-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H25N3O.ClH/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21;/h1-9,16,19,23H,10-15H2,(H,24,26);1H

InChIKey

AFJSFHAKSSWOKG-UHFFFAOYSA-N

Smiles

c12c(c[nH]c1cccc2)CCN1CCC(NC(c2ccccc2)=O)CC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 450mg/kg (450mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 161, 1980.
mouse LD50 oral 1gm/kg (1000mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 161, 1980.
rat LD50 intraperitoneal 500mg/kg (500mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 161, 1980.
rat LD50 oral 1800mg/kg (1800mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 161, 1980.
women TDLo oral 7mg/kg/1W-I (7mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: WAKEFULNESS

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Practitioner. Vol. 228, Pg. 362, 1984.