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Substance Name: Galanthamine methiodide
RN: 3891-74-5
InChIKey: BGQUXEGIISTLGG-PFYMQUAWSA-M

Note

  • A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.

Molecular Formula

  • C18-H24-N-O3.I

Molecular Weight

  • 429.292
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Galanthamine methiodide

Synonyms

  • Galanthamine iodomethylate
  • Galanthamine methiodide
  • Galanthaminium, 10-methyl-, iodide

Systematic Names

  • Galanthaminium, 7-methyl-, iodide
  • N-Methylgalanthaminium iodide (7CI)

Registry Numbers

CAS Registry Number

  • 3891-74-5

System Generated Number

  • 0003891745

Molecular Formulas

Molecular Formula

  • C18-H24-N-O3.I

Molecular Formula Fragments

  • C18-H24-N-O3
  • COMPONENT
  • I

Structure Descriptors

InChI

1S/C18H24NO3.HI/c1-19(2)9-8-18-7-6-13(20)10-15(18)22-17-14(21-3)5-4-12(11-19)16(17)18;/h4-7,13,15,20H,8-11H2,1-3H3;1H/q+1;/p-1/t13-,15-,18?;/m0./s1

InChIKey

BGQUXEGIISTLGG-PFYMQUAWSA-M

Smiles

c12ccc(c3O[C@@H]4[C@@](c13)(C=C[C@@H](C4)O)CC[N+](C2)(C)C)OC.[IH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4250ug/kg (4.25mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 25, Pg. 168, 1962.
mouse LD50 intravenous 1320ug/kg (1.32mg/kg) BEHAVIORAL: EXCITEMENT

PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 25, Pg. 168, 1962.
mouse LD50 oral 98mg/kg (98mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 25, Pg. 168, 1962.
mouse LD50 subcutaneous 7100ug/kg (7.1mg/kg) BEHAVIORAL: EXCITEMENT

PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Farmakologiya i Toksikologiya Vol. 25, Pg. 168, 1962.