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Substance Name: Emorfazone [INN:JAN]
RN: 38957-41-4
UNII: V93U9DH62C
InChIKey: URJQOOISAKEBKW-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C11-H17-N3-O3

Molecular Weight

  • 239.273
 
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Names and Synonyms

Name of Substance

  • Emorfazone
  • Emorfazone [INN:JAN]

Synonyms

  • 4-Ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone
  • 4-Ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone
  • BRN 0995465
  • EINECS 254-220-9
  • Emorfazona
  • Emorfazona [INN-Spanish]
  • Emorfazone
  • Emorfazone [INN-French]
  • Emorfazonum
  • Emorfazonum [INN-Latin]
  • M 73101
  • M73101
  • Nandron
  • UNII-V93U9DH62C

Systematic Names

  • 3(2H)-Pyridazinone, 4-ethoxy-2-methyl-5-morpholino-
  • 4-Ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone
  • 4-Ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone
  • Emorfazone

Registry Numbers

CAS Registry Number

  • 38957-41-4

FDA UNII

  • V93U9DH62C

System Generated Number

  • 0038957414

Structure Descriptors

InChI

1S/C11H17N3O3/c1-3-17-10-9(8-12-13(2)11(10)15)14-4-6-16-7-5-14/h8H,3-7H2,1-2H3

InChIKey

URJQOOISAKEBKW-UHFFFAOYSA-N

Smiles

c1(c(c(n(C)nc1)=O)OCC)N1CCOCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 310mg/kg (310mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 intraperitoneal 620mg/kg (620mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 intravenous 305mg/kg (305mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 oral 960mg/kg (960mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 subcutaneous 750mg/kg (750mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
rabbit LD50 intravenous 230mg/kg (230mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
rabbit LD50 oral 840mg/kg (840mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
rat LD50 intraperitoneal 600mg/kg (600mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
rat LD50 intravenous 340mg/kg (340mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
rat LD50 oral 1900mg/kg (1900mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
rat LD50 subcutaneous 720mg/kg (720mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 90 deg C   EXP
log P (octanol-water) -1.790 (none)   EST
Atmospheric OH Rate Constant 1.95E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.