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Substance Name: Derricin
RN: 38965-77-4
InChIKey: HMGRVRIPKPTWTO-JLHYYAGUSA-N

Note

  • Has antineoplastic activity; inhibits Wnt/beta-catenin signaling; isolated from Lonchocarpus sericeus.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C21-H22-O3

Molecular Weight

  • 322.4018
 
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Names and Synonyms

Results Name

  • Derricin

Synonyms

  • Acrylophenone, 2'-hydroxy-4'-methoxy-3'-(3-methyl-2-butenyl)-3-phenyl-, (E)-
  • Derricin
  • trans-1-(2-Hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-2-propen-1-one

Systematic Name

  • 2-Propen-1-one, 1-(2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-, (E)-

Registry Numbers

CAS Registry Number

  • 38965-77-4

System Generated Number

  • 0038965774

Structure Descriptors

InChI

1S/C21H22O3/c1-15(2)9-11-18-20(24-3)14-12-17(21(18)23)19(22)13-10-16-7-5-4-6-8-16/h4-10,12-14,23H,11H2,1-3H3/b13-10+

InChIKey

HMGRVRIPKPTWTO-JLHYYAGUSA-N

Smiles

CC(=CCc1c(ccc(c1O)C(=O)/C=C/c2ccccc2)OC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 275mg/kg (275mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 295, 1982.