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Substance Name: Aphidicolin
RN: 38966-21-1
UNII: 192TJ6PP19
InChIKey: NOFOAYPPHIUXJR-APNQCZIXSA-N

Note

  • An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Molecular Formula

  • C20-H34-O4

Molecular Weight

  • 338.4846
 

Classification Codes

  • Anti-Infective Agents
  • Antiviral Agents
  • Enzyme Inhibitors
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Aphidicolin

MeSH Heading

  • Aphidicolin

Synonyms

  • Aphidicolin
  • BRN 4689958
  • CCRIS 1783
  • ICI 69653
  • NSC 234714
  • NSC-234714
  • UNII-192TJ6PP19

Systematic Names

  • 8,11a-Methano-11aH-cyclohepta(a)naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R-(3-alpha,4-alpha,4a-alpha,6a-beta,8-beta,9-beta,11a-beta,11b-beta))-
  • 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-
  • Aphidicolin

Registry Numbers

CAS Registry Number

  • 38966-21-1

FDA UNII

  • 192TJ6PP19

System Generated Number

  • 0038966211

Structure Descriptors

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChIKey

NOFOAYPPHIUXJR-APNQCZIXSA-N

Smiles

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]3C[C@@H]4C[C@]23CC[C@]4(O)CO