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Substance Name: Methoxamine [INN:BAN]
RN: 390-28-3
UNII: HUQ1KC1YLI
InChIKey: WJAJPNHVVFWKKL-CPCISQLKSA-N

Note

  • An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.

Molecular Formula

  • C11-H17-N-O3

Molecular Weight

  • 211.2593
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-1 Receptor Agonists
  • Adrenergic alpha-Agonists
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympathomimetics
  • Vasoconstrictor Agents
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Names and Synonyms

Results Name

  • Methoxamine [INN:BAN]

Name of Substance

  • Methoxamine
  • Methoxamine [INN:BAN]

MeSH Heading

  • Methoxamine

Synonyms

  • 2-Amino-1-(2,5-dimethoxyphenyl)propanol
  • alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol
  • DL-2-Amino-1-(2,5-dimethoxyphenyl)propanol
  • EINECS 206-867-3
  • Methoxamedrine
  • Methoxamin
  • Methoxamine
  • Methoxaminum
  • Methoxaminum [INN-Latin]
  • Metossamina
  • Metossamina [DCIT]
  • Metoxamina
  • Metoxamina [INN-Spanish]
  • Pseudomethoxamine
  • UNII-HUQ1KC1YLI

Systematic Names

  • Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-
  • Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy-
  • Methoxamine

Registry Numbers

CAS Registry Number

  • 390-28-3

FDA UNII

  • HUQ1KC1YLI

Related Registry Number

  • 61-16-5 (hydrochloride)

System Generated Number

  • 0000390283

Structure Descriptors

InChI

1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3/t7-,11-/m0/s1

InChIKey

WJAJPNHVVFWKKL-CPCISQLKSA-N

Smiles

COc1ccc(OC)c(c1)[C@@H](O)[C@H](C)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 69mg/kg (69mg/kg) CARDIAC: OTHER CHANGES Journal of Pharmacology and Experimental Therapeutics. Vol. 160, Pg. 22, 1968.
mouse LD50 oral 30mg/kg (30mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse LD50 subcutaneous 30mg/kg (30mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.380 (none)   EST
Atmospheric OH Rate Constant 9.76E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.