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Substance Name: Fludiazepam [INN:JAN]
RN: 3900-31-0
UNII: 7F64A2K16Z
InChIKey: ROYOYTLGDLIGBX-UHFFFAOYSA-N

Molecular Formula

  • C16-H12-Cl-F-N2-O

Molecular Weight

  • 302.7348
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Fludiazepam
  • Fludiazepam [INN:JAN]

Synonyms

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-
  • 5-24-04-00320 (Beilstein Handbook Reference)
  • 7-Chloro-5-(2-fluorophenyl)-1-methyl-1H-1,4-benzodiazepin-2(3H)-one
  • BRN 0686115
  • Erispan
  • Fludiazepam
  • Fludiazepamum
  • Fludiazepamum [INN-Latin]
  • ID 540
  • Ro 5-3438
  • UNII-7F64A2K16Z

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-1-methyl-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl- (9CI)
  • 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

Superlist Names

  • DEA No. 2759
  • Fludiazepam

Registry Numbers

CAS Registry Number

  • 3900-31-0

FDA UNII

  • 7F64A2K16Z

Other Registry Number

  • 60918-52-7

System Generated Number

  • 0003900310

Structure Descriptors

InChI

InChI=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3

InChIKey

ROYOYTLGDLIGBX-UHFFFAOYSA-N

Smiles

CN1C(=O)CN=C(c2ccccc2F)c3cc(Cl)ccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 360mg/kg (360mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1563, 1974.
mouse LD50 oral 830mg/kg (830mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1563, 1974.
rat LD50 intraperitoneal 315mg/kg (315mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
rat LD50 oral 1740mg/kg (1740mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 811, 1980.
rat LD50 subcutaneous 7600mg/kg (7600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 295-297 deg C   EXP
log P (octanol-water) 2.75 (none)   EXP
Water Solubility 53 mg/L 25 EST
Vapor Pressure 3.35E-08 mm Hg 25 EST
Henry's Law Constant 4.25E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.54E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.