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Substance Name: Sotalol [INN:BAN]
RN: 3930-20-9
UNII: A6D97U294I
InChIKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N

Note

  • An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.

Molecular Formula

  • C12-H20-N2-O3-S

Molecular Weight

  • 272.367
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympatholytics

Names and Synonyms

Results Name

  • Sotalol [INN:BAN]

Name of Substance

  • Sotalol
  • Sotalol [INN:BAN]

MeSH Heading

  • Sotalol

Synonyms

  • (+-)-Sotalol
  • 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide
  • 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid
  • beta-Cardone
  • CCRIS 4204
  • dl-Sotalol
  • Sotalol
  • Sotalolum
  • Sotalolum [INN-Latin]
  • UNII-A6D97U294I

Systematic Names

  • Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)- (9CI)
  • Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)-
  • Sotalol

Registry Numbers

CAS Registry Number

  • 3930-20-9

FDA UNII

  • A6D97U294I

Other Registry Number

  • 27948-47-6

Related Registry Number

  • 959-24-0 (mono-hydrochloride)

System Generated Number

  • 0003930209

Structure Descriptors

InChI

1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3

InChIKey

ZBMZVLHSJCTVON-UHFFFAOYSA-N

Smiles

CC(C)NCC(c1ccc(cc1)NS(=O)(=O)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 3429ug/kg/2D- (3.429mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: PULSE RATE
Australian and New Zealand Journal of Medicine. Vol. 24, Pg. 319, 1994.
mouse LD50 intraperitoneal 790mg/kg (790mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 145, 1973.
mouse LD50 intravenous 113mg/kg (113mg/kg)   United States Patent Document. Vol. #5118689,
women LDLo oral 288mg/kg (288mg/kg) CARDIAC: CHANGE IN RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: COMA
Journal of Toxicology, Clinical Toxicology. Vol. 26, Pg. 389, 1988.
women TDLo multiple routes 100mg/kg/2W-I (100mg/kg) CARDIAC: OTHER CHANGES American Heart Journal. Vol. 107, Pg. 179, 1984.
women TDLo oral 14mg/kg/3D-I (14mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Australian and New Zealand Journal of Medicine. Vol. 24, Pg. 319, 1994.
women TDLo oral 118mg/kg/4W-I (118mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE

CARDIAC: CHANGE IN RATE
Postgraduate Medical Journal. Vol. 68, Pg. 289, 1992.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 206.5-207 deg C   EXP
log P (octanol-water) 0.24 (none)   EXP
Water Solubility 5510 mg/L 25 EST
Vapor Pressure 5.30E-09 mm Hg 25 EST
Henry's Law Constant 2.49E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.53E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.