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Substance Name: Sotalol [INN:BAN]
RN: 3930-20-9
UNII: A6D97U294I
InChIKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N
Note
- An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Molecular Formula
- C12-H20-N2-O3-S
Molecular Weight
- 272.367
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Antagonists
- Adrenergic beta-Antagonists
- Anti-Arrhythmia Agents
- Autonomic Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sympatholytics
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Names and Synonyms
Results Name
- Sotalol [INN:BAN]
Name of Substance
- Sotalol
- Sotalol [INN:BAN]
MeSH Heading
- Sotalol
Synonyms
- (+-)-Sotalol
- 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide
- 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid
- beta-Cardone
- CCRIS 4204
- dl-Sotalol
- Sotalol
- Sotalolum
- Sotalolum [INN-Latin]
- UNII-A6D97U294I
Systematic Names
- Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-
- Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)-
- Sotalol
Registry Numbers
CAS Registry Number
- 3930-20-9
FDA UNII
- A6D97U294I
Other Registry Number
- 27948-47-6
Related Registry Number
- 959-24-0 (mono-hydrochloride)
System Generated Number
- 0003930209
Structure Descriptors
InChI
InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3InChIKey
ZBMZVLHSJCTVON-UHFFFAOYSA-NSmiles
CC(C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 3429ug/kg/2D- (3.429mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: PULSE RATE | Australian and New Zealand Journal of Medicine. Vol. 24, Pg. 319, 1994. |
| mouse | LD50 | intraperitoneal | 790mg/kg (790mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 145, 1973. |
| mouse | LD50 | intravenous | 113mg/kg (113mg/kg) | United States Patent Document. Vol. #5118689, | |
| women | LDLo | oral | 288mg/kg (288mg/kg) | CARDIAC: CHANGE IN RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: COMA | Journal of Toxicology, Clinical Toxicology. Vol. 26, Pg. 389, 1988. |
| women | TDLo | multiple routes | 100mg/kg/2W-I (100mg/kg) | CARDIAC: OTHER CHANGES | American Heart Journal. Vol. 107, Pg. 179, 1984. |
| women | TDLo | oral | 14mg/kg/3D-I (14mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Australian and New Zealand Journal of Medicine. Vol. 24, Pg. 319, 1994. |
| women | TDLo | oral | 118mg/kg/4W-I (118mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE CARDIAC: CHANGE IN RATE | Postgraduate Medical Journal. Vol. 68, Pg. 289, 1992. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 206.5-207 | deg C | EXP | |
| log P (octanol-water) | 0.24 | (none) | EXP | |
| Water Solubility | 5510 | mg/L | 25 | EST |
| Vapor Pressure | 5.30E-09 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.49E-14 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.53E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.