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Substance Name: Picibanil
RN: 39325-01-4
UNII: 2F42BH7X2L
InChIKey: JGSARLDLIJGVTE-MBNYWOFBSA-M

Note

  • A lyophilized preparation of a low-virulence strain (SU) of Streptococcus pyogenes (S. hemolyticus), inactivated by heating with penicillin G. It has been proposed as a noncytotoxic antineoplastic agent because of its immune system-stimulating activity.

Molecular Formula

  • Unspecified

Molecular Weight

  • 333.3863
 

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Name of Substance

  • Picibanil

MeSH Heading

  • Picibanil

Synonyms

  • CCRIS 2776
  • OK 432
  • Picibanil
  • Sapylin
  • UNII-2F42BH7X2L

Systematic Name

  • Picibanil

Registry Numbers

CAS Registry Number

  • 39325-01-4

FDA UNII

  • 2F42BH7X2L

Other Registry Number

  • 59680-53-4

System Generated Number

  • 0039325014

Structure Descriptors

InChI

1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/p-1/t11-,12+,14-/m1/s1

InChIKey

JGSARLDLIJGVTE-MBNYWOFBSA-M

Smiles

N12[C@@H]([C@@H](C1=O)NC(=O)Cc1ccccc1)SC([C@@H]2C(=O)[O-])(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 125mg/kg (125mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse LD50 intravenous 24500ug/kg (24.5mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse LD50 subcutaneous 197mg/kg (197mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
rat LD50 intraperitoneal 160mg/kg (160mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
rat LD50 intravenous 25mg/kg (25mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
rat LD50 subcutaneous 405mg/kg (405mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.