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Substance Name: Nocardicin A
RN: 39391-39-4
UNII: R76HLW7Z19
InChIKey: CTNZOGJNVIFEBA-UPSUJEDGSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C23-H24-N4-O9

Molecular Weight

  • 500.4616
 
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Names and Synonyms

Name of Substance

  • Nocardicin A

Synonyms

  • Antibiotic FR 1923
  • FR-1923-C
  • Nocardicin A
  • UNII-R76HLW7Z19

Systematic Name

  • 1-Azetidineacetic acid, 3-(((4-(3-amino-3-carboxypropoxy)phenyl)(hydroxyimino)acetyl)amino)-alpha-(4-hydroxyphenyl)-2-oxo-, (3S-(1(S*),3R*(Z(S*))))-

Registry Numbers

CAS Registry Number

  • 39391-39-4

FDA UNII

  • R76HLW7Z19

System Generated Number

  • 0039391394

Structure Descriptors

InChI

1S/C23H24N4O9/c24-16(22(31)32)9-10-36-15-7-3-12(4-8-15)18(26-35)20(29)25-17-11-27(21(17)30)19(23(33)34)13-1-5-14(28)6-2-13/h1-8,16-17,19,28,35H,9-11,24H2,(H,25,29)(H,31,32)(H,33,34)/b26-18-/t16-,17+,19-/m1/s1

InChIKey

CTNZOGJNVIFEBA-UPSUJEDGSA-N

Smiles

N[C@H](CCOc1ccc(cc1)\C(=N\O)\C(=O)N[C@H]2CN([C@@H](C(=O)O)c3ccc(O)cc3)C2=O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2500mg/kg (2500mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
mouse LD50 intravenous 2100mg/kg (2100mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
mouse LD50 oral > 8gm/kg (8000mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
mouse LD50 subcutaneous 2900mg/kg (2900mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
rat LD50 intraperitoneal 2600mg/kg (2600mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
rat LD50 intravenous > 2gm/kg (2000mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
rat LD50 oral > 8gm/kg (8000mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.
rat LD50 subcutaneous 3100mg/kg (3100mg/kg)   Journal of Antibiotics. Vol. 29, Pg. 492, 1976.