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Substance Name: Befunolol hydrochloride [JAN]
RN: 39543-79-8
UNII: B03Z2VY37I
InChIKey: TVVTWOGRPVJKDJ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C16-H21-N-O4.Cl-H

Molecular Weight

  • 327.806
 
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Names and Synonyms

Name of Substance

  • Befunolol hydrochloride
  • Befunolol hydrochloride [JAN]

Synonyms

  • 1-(7-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)ethanone hydrochloride
  • 2-Acetyl-7-((2-hydroxy-3-isopropylamino)propoxy)benzofuran hydrochloride
  • Befunolol HCl
  • Befunolol hydrochloride
  • Bentox
  • BFE 60
  • Glauconex
  • UNII-B03Z2VY37I

Systematic Name

  • Ethanone, 1-(7-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 39543-79-8

FDA UNII

  • B03Z2VY37I

Related Registry Number

  • 39552-01-7 (Parent)

System Generated Number

  • 0039543798

Molecular Formulas

Molecular Formula

  • C16-H21-N-O4.Cl-H

Molecular Formula Fragments

  • C16-H21-N-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H21NO4.ClH/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14;/h4-7,10,13,17,19H,8-9H2,1-3H3;1H

InChIKey

TVVTWOGRPVJKDJ-UHFFFAOYSA-N

Smiles

c12c(cc(o2)C(C)=O)cccc1OC[C@@H](C[NH2+]C(C)C)O.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 184mg/kg (184mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.
mouse LD50 intravenous 65mg/kg (65mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.
mouse LD50 oral 950mg/kg (950mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.
mouse LD50 subcutaneous 434mg/kg (434mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.
rabbit LD50 oral 400mg/kg (400mg/kg)   Drugs in Japan Vol. -, Pg. 1086, 1990.
rat LD50 intraperitoneal 182mg/kg (182mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.
rat LD50 oral 922mg/kg (922mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.
rat LD50 subcutaneous 498mg/kg (498mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 3225, 1979.