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Substance Name: Triamterene [USAN:USP:INN:BAN:JAN]
RN: 396-01-0
UNII: WS821Z52LQ
InChIKey: FNYLWPVRPXGIIP-UHFFFAOYSA-N

Note

  • A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.

Molecular Formula

  • C12-H11-N7

Molecular Weight

  • 253.2679
 

Classification Codes

  • Diuretic
  • Diuretics
  • Diuretics, Potassium Sparing
  • Drug / Therapeutic Agent
  • Epithelial Sodium Channel Blockers
  • Human Data
  • Membrane Transport Modulators
  • Mutation Data
  • Natriuretic Agents
  • Sodium Channel Blockers
  • Tumor Data

Names and Synonyms

Name of Substance

  • Triamterene
  • Triamterene [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Triamterene

Synonyms

  • 2,4,7-Pteridinetriamine, 6-phenyl-
  • 2,4,7-Triamino-6-fenilpteridina
  • 2,4,7-Triamino-6-fenilpteridina [Italian]
  • 2,4,7-Triamino-6-phenylpteridine
  • 5-26-17-00447 (Beilstein Handbook Reference)
  • 6-Phenyl-2,4,7-pteridinetriamine
  • 6-Phenyl-2,4,7-triaminopteridine
  • Ademin
  • Ademin(e)
  • Ademine
  • AI3-60017
  • Amteren
  • Anjal
  • Apo-triazide
  • BRN 0266723
  • CCRIS 5872
  • Dazid
  • Diarol
  • Dinazide
  • Diren
  • Ditak
  • Diucelpin
  • Diurene
  • Diutensat
  • Diuteren
  • Dyberzide
  • Dyren
  • Dyrenium
  • Dytac
  • Dytenzide
  • EINECS 206-904-3
  • Esiteren
  • Fluss 40
  • Hidiurese
  • HSDB 3405
  • Hydrene
  • Hypertorr
  • Isobar
  • Jatropur
  • Jenateren
  • Kalspare
  • Masuharmin
  • NCI C56042
  • Nephral
  • Noridil
  • Noridyl
  • NSC 639359
  • NSC 77625
  • Pteridine, 2,4,7-triamino-6-phenyl-
  • Pterofen
  • Pterophene
  • Renezide
  • Reviten
  • SALI-PUREN
  • SK&F 8542
  • SKF 8542
  • Taturil
  • Teriam
  • Teridin
  • Thiazid Wolff
  • Tri-Span
  • Triamizide
  • Triampur
  • Triamteren
  • Triamterena
  • Triamterena [INN-Spanish]
  • Triamterene
  • Triamterenum
  • Triamterenum [INN-Latin]
  • Triamteril
  • Triamteril complex
  • Triamthiazid
  • Triazide
  • Tricilone
  • Trispan
  • Triteren
  • Triurene
  • Trizid
  • Turfa
  • UNII-WS821Z52LQ
  • Uretren
  • Urocaudal

Systematic Names

  • 2,4,7-Pteridinetriamine, 6-phenyl-
  • Pteridine, 2,4,7-triamino-6-phenyl-
  • Triamterene

Superlist Name

  • Triamterene

Mixture Names

  • Dyazide
  • Maxzide

Registry Numbers

CAS Registry Number

  • 396-01-0

FDA UNII

  • WS821Z52LQ

System Generated Number

  • 0000396010

Structure Descriptors

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

InChIKey

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Smiles

c1ccc(cc1)c2c(nc3c(n2)c(nc(n3)N)N)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 249mg/kg (249mg/kg)   Drugs in Japan Vol. 6, Pg. 519, 1982.
mouse LD50 intravenous 25077ug/kg (25.077mg/kg)   Pharmazie. Vol. 50, Pg. 419, 1995.
mouse LD50 oral 285mg/kg (285mg/kg)   French Demande Patent Document. Vol. #2314719,
mouse LD50 subcutaneous 620mg/kg (620mg/kg)   Drugs in Japan Vol. 6, Pg. 519, 1982.
mouse LDLo unreported 25mg/kg (25mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1688, 1985.
rat LD50 intraperitoneal 200mg/kg (200mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
rat LD50 oral 400mg/kg (400mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
women TDLo oral 42mg/kg/3W-I (42mg/kg)   Medical Journal of Australia. Vol. 147, Pg. 262, 1987.
women TDLo oral 42mg/kg/3W-I (42mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" Medical Journal of Australia. Vol. 147, Pg. 262, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 316 deg C   EXP
log P (octanol-water) 0.98 (none)   EXP
Water Solubility 48.2 mg/L 25 EST
Vapor Pressure 1.09E-11 mm Hg 25 EST
Henry's Law Constant 1.86E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.03E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.