Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Talampicillin hydrochloride [USAN:JAN]
RN: 39878-70-1
UNII: 4C5O3X072I
InChIKey: PAZSYTCTHYSIAO-WVFSJLEKSA-N

Note

  • An ester of AMPICILLIN which is readily hydrolysed on absorption to release ampicillin. It is well absorbed from the gastrointestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin.

Molecular Formula

  • C24-H23-N3-O6-S.Cl-H

Molecular Weight

  • 517.988
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Antibiotics
  • Drug / Therapeutic Agent
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Talampicillin hydrochloride
  • Talampicillin hydrochloride [USAN:JAN]

Synonyms

  • (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid ester with 3-hydroxyphthalide, monohydrochloride
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, monohydrochloride, (2S-(2alpha,5alpha,6beta(S*)))-
  • BRL 8988
  • BRL 8988 Hydrochloride
  • Talampicillin HCl
  • Talampicillin hydrochloride
  • Talpen
  • UNII-4C5O3X072I
  • Yamacillin

Systematic Name

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, monohydrochloride, (2S-(2alpha,5alpha,6beta(S*)))-

Registry Numbers

CAS Registry Number

  • 39878-70-1

FDA UNII

  • 4C5O3X072I

System Generated Number

  • 0039878701

Molecular Formulas

Molecular Formula

  • C24-H23-N3-O6-S.Cl-H

Molecular Formula Fragments

  • C24-H23-N3-O6-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C24H23N3O6S.ClH/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12;/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28);1H/t15-,16-,17+,20-,23?;/m1./s1

InChIKey

PAZSYTCTHYSIAO-WVFSJLEKSA-N

Smiles

O1[C@@H](c2c(C1=O)cccc2)OC([C@H]1C(S[C@H]2N1C([C@H]2NC([C@H](N)c1ccccc1)=O)=O)(C)C)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 441, 1982.
mouse LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 441, 1982.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 441, 1982.
rat LD50 intravenous 786mg/kg (786mg/kg)   Drugs in Japan Vol. 6, Pg. 441, 1982.
rat LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 441, 1982.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 441, 1982.