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Substance Name: Nitroxoline [INN:BAN:DCF]
RN: 4008-48-4
UNII: A8M33244M6
InChIKey: RJIWZDNTCBHXAL-UHFFFAOYSA-N

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Urinary
  • Antifungal Agents
  • Renal Agents
  • Tumor Data

Molecular Formula

  • C9-H6-N2-O3

Molecular Weight

  • 190.1574
 
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Names and Synonyms

Name of Substance

  • Nitroxoline
  • Nitroxoline [INN:BAN:DCF]

Synonyms

  • 5-21-03-00297 (Beilstein Handbook Reference)
  • 5-Nitro-8-hydroxyquinoline
  • 5-Nitro-8-oxychinoline
  • 5-Nitro-8-oxyquinoline
  • 5-Nitro-8-quinolinol
  • 5-Nitroks
  • 5-Nitrox
  • 5-Nitroxine
  • 5-NOK
  • 5NOK
  • 8-Hydroxy-5-nitroquinoline
  • A-82
  • BAS 58
  • BRN 0166146
  • EINECS 223-662-4
  • Galinok
  • Isinok
  • Nibiol
  • Nicene Forte
  • Nitroxolin
  • Nitroxolina
  • Nitroxolina [INN-Spanish]
  • Nitroxoline
  • Nitroxolinum
  • Nitroxolinum [INN-Latin]
  • Noxibiol
  • Noxin
  • NSC 74947
  • UNII-A8M33244M6
  • Uro-Coli

Systematic Names

  • 5-Nitro-8-quinolinol
  • 8-Quinolinol, 5-nitro-
  • Nitroxoline

Registry Numbers

CAS Registry Number

  • 4008-48-4

FDA UNII

  • A8M33244M6

System Generated Number

  • 0004008484

Structure Descriptors

InChI

1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H

InChIKey

RJIWZDNTCBHXAL-UHFFFAOYSA-N

Smiles

c1cc2c(ccc(c2nc1)O)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 8300ug/kg (8.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Toxikologie. Vol. 20, Pg. 313, 1965.
mouse LD50 oral 104mg/kg (104mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Toxikologie. Vol. 20, Pg. 313, 1965.
rat LD50 oral 510mg/kg (510mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Toxikologie. Vol. 20, Pg. 313, 1965.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 180 deg C   EXP
log P (octanol-water) 1.99 (none)   EXP
Water Solubility 3730 mg/L 25 EST
Vapor Pressure 2.13E-06 mm Hg 25 EST
Henry's Law Constant 2.83E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.30E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.