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Substance Name: Ticrynafen [USAN]
RN: 40180-04-9
UNII: HC95205SY4
InChIKey: AGHANLSBXUWXTB-UHFFFAOYSA-N

Note

  • A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.

Molecular Formula

  • C13-H8-Cl2-O4-S

Molecular Weight

  • 331.1742
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Antirheumatic Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Gout Suppressants
  • Human Data
  • Mutation Data
  • Natriuretic Agents
  • Renal Agents
  • Uricosuric
  • Uricosuric Agents
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Names and Synonyms

Name of Substance

  • Ticrynafen
  • Ticrynafen [USAN]
  • Tienilic acid [INN]

MeSH Heading

  • Ticrynafen

Synonyms

  • (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid
  • (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid
  • (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid
  • 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure
  • 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure [German]
  • 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid
  • 5-18-02-00008 (Beilstein Handbook Reference)
  • Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-
  • Acide tienilique
  • Acide tienilique [INN-French]
  • Acido tienilico
  • Acido tienilico [INN-Spanish]
  • Acidum tienilicum
  • Acidum tienilicum [INN-Latin]
  • ANP 3624
  • BRN 1260086
  • CCRIS 5489
  • CE 3624
  • Diflurex
  • EINECS 254-826-3
  • FR 3068
  • Selacryn
  • SK&F 62698
  • SKF 62698
  • Thienylic acid
  • Ticrex
  • Ticrynafen
  • Tienilic acid
  • Tienilico acido
  • Tienilico acido [Spanish]
  • UNII-HC95205SY4

Systematic Names

  • Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-
  • Tienilic acid

Registry Numbers

CAS Registry Number

  • 40180-04-9

FDA UNII

  • HC95205SY4

System Generated Number

  • 0040180049

Structure Descriptors

InChI

1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)

InChIKey

AGHANLSBXUWXTB-UHFFFAOYSA-N

Smiles

OC(=O)COc1ccc(C(=O)c2cccs2)c(Cl)c1Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 3571ug/kg (3.571mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Clinical Toxicology. Vol. 18, Pg. 425, 1981.
man TDLo oral 6666ug/kg (6.666mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" New England Journal of Medicine. Vol. 301, Pg. 1180, 1979.
mouse LD50 intraperitoneal 318mg/kg (318mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Drugs of the Future. Vol. 13, Pg. 257, 1988.
mouse LD50 intravenous 225mg/kg (225mg/kg)   United States Patent Document. Vol. #3758506,
mouse LD50 oral 1275mg/kg (1275mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 625, 1974.
women TDLo oral 5mg/kg (5mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

GASTROINTESTINAL: NAUSEA OR VOMITING
New England Journal of Medicine. Vol. 301, Pg. 1179, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 149 deg C   EXP
log P (octanol-water) 3.590 (none)   EST
Atmospheric OH Rate Constant 1.75E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.