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Substance Name: p-Methyl diphenhydramine hydrochloride
RN: 4024-34-4
UNII: 8H4DV0TDRY
InChIKey: BNFDLGUZDIWYJK-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H23-N-O.Cl-H

Molecular Weight

  • 305.847
 
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Names and Synonyms

Name of Substance

  • p-Methyl diphenhydramine hydrochloride

Synonyms

  • EINECS 223-691-2
  • Ethylamine, N,N-dimethyl-2-((p-methyl-alpha-phenylbenzyl)oxy)-, hydrochloride
  • N,N-Dimethyl-2-((p-methyl-alpha-phenylbenzyl)oxy)ethylamine hydrochloride
  • N,N-Dimethyl-2-(alpha-(p-tolyl)benzyloxy)ethylamine hydrochloride
  • Neo-benodine
  • Toladryl
  • Toladryl hydrochloride
  • UNII-8H4DV0TDRY

Systematic Names

  • 2-((p-Methyl-alpha-phenylbenzyl)oxy)ethyl(dimethyl)ammonium chloride
  • Ethylamine, N,N-dimethyl-2-(alpha-(p-tolyl)benzyloxy)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 4024-34-4

FDA UNII

  • 8H4DV0TDRY

System Generated Number

  • 0004024344

Molecular Formulas

Molecular Formula

  • C18-H23-N-O.Cl-H

Molecular Formula Fragments

  • C18-H23-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H23NO.ClH/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16;/h4-12,18H,13-14H2,1-3H3;1H

InChIKey

BNFDLGUZDIWYJK-UHFFFAOYSA-N

Smiles

c1([C@@H](c2ccccc2)OCC[NH+](C)C)ccc(C)cc1.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 150mg/kg (150mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 318, 1954.
mouse LD50 intravenous 45mg/kg (45mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 964, 1964.
mouse LD50 oral 350mg/kg (350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 964, 1964.
mouse LDLo subcutaneous 325mg/kg (325mg/kg)   Cesko-Slovenska Farmacie. Vol. 3, Pg. 272, 1954.