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Substance Name: 4-Hydroxycyclophosphamide
RN: 40277-05-2
UNII: 1XBF4E50HS
InChIKey: RANONBLIHMVXAJ-UHFFFAOYSA-N

Note

  • Primary activation metabolite of cyclophosphamide.

Molecular Formula

  • C7-H15-Cl2-N2-O3-P

Molecular Weight

  • 277.086
 
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Names and Synonyms

Name of Substance

  • 4-Hydroxycyclophosphamide

Synonyms

  • 4-Hydroperoxydechlorocyclophosphamide
  • 4-Hydroxycyclophosphamide
  • BRN 0526395
  • CCRIS 5125
  • NSC 196562
  • Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
  • UNII-1XBF4E50HS

Systematic Names

  • 2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
  • 2H-1,3,2-Oxazaphosphorin-4-ol, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide (9CI)
  • 2H-1,3,2-Oxazaphosphorin-4-ol, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide
  • 4-Hydroxycyclophosphamide

Registry Numbers

CAS Registry Number

  • 40277-05-2

FDA UNII

  • 1XBF4E50HS

System Generated Number

  • 0040277052

Structure Descriptors

InChI

1S/C7H15Cl2N2O3P/c8-2-4-11(5-3-9)15(13)10-7(12)1-6-14-15/h7,12H,1-6H2,(H,10,13)

InChIKey

RANONBLIHMVXAJ-UHFFFAOYSA-N

Smiles

N1[P@@](N(CCCl)CCCl)(OCC[C@@H]1O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,