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Substance Name: Fenfluramine hydrochloride [USAN]
RN: 404-82-0
UNII: 3KC089243P
InChIKey: ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Note

  • A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.

Molecular Formula

  • C12-H16-F3-N.Cl-H

Molecular Weight

  • 267.7203
 

Classification Codes

Classification Codes

  • Anorexic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Fenfluramine hydrochloride [USAN]

MeSH Heading

  • Fenfluramin

Synonyms

  • (+-)-Fenfluramine
  • (+-)-Fenfluramine chloride
  • (+-)-Fenfluramine hydrochloride
  • 1-(3-Trifluoromethylphenyl)-2-ethylaminopropane hydrochloride
  • 1-(m-Trifluoromethylphenyl)-2-(ethylamino)propane hydrochloride
  • AHR 3002
  • AHR-3002
  • dl-Fenfluramine hydrochloride
  • EINECS 206-968-2
  • Fenfluramine HCl
  • Fenfluramine hydrochloride
  • Ganal
  • N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride (+-)-
  • N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine hydrochloride
  • N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride
  • Phenfluoramine hydrochloride
  • Ponderal
  • Ponderax
  • Pondimin
  • Racemic fenfluramine hydrochloride
  • UNII-3KC089243P
  • ZX008

Systematic Names

  • Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, hydrochloride
  • Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, hydrochloride, (+-)-
  • Fenfluramine hydrochloride
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-, hydrochloride
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-, hydrochloride, (+-)-

Superlist Names

  • DEA No. 1670
  • Fenfluramine
  • Ponderal
  • Pondimin

Registry Numbers

CAS Registry Number

  • 404-82-0

FDA UNII

  • 3KC089243P

Other Registry Number

  • 16105-77-4

Related Registry Number

  • 458-24-2 (Parent)

System Generated Number

  • 0000404820

Molecular Formulas

Molecular Formula

  • C12-H16-F3-N.Cl-H

Molecular Formula Fragments

  • C12-H16-F3-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChIKey

ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Smiles

Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 60mg/kg (60mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
child LDLo oral 70mg/kg (70mg/kg) CARDIAC: OTHER CHANGES Clinical Toxicology. Vol. 14, Pg. 97, 1979.
dog LD50 intravenous 23mg/kg (23mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969.
dog LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
guinea pig LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
human TDLo oral 7mg/kg (7mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
British Medical Journal. Vol. 1, Pg. 740, 1967.
mouse LD50 intraperitoneal 92mg/kg (92mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1561, 1978.
mouse LD50 intravenous 90mg/kg (90mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
mouse LD50 oral 170mg/kg (170mg/kg)   Therapie. Vol. 20, Pg. 297, 1965.
rabbit LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY

BEHAVIORAL: TREMOR
Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
rat LD50 intraperitoneal 90mg/kg (90mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
rat LD50 oral 69mg/kg (69mg/kg) BEHAVIORAL: FLUID INTAKE Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969.
women TDLo oral 36mg/kg (36mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SLEEP

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 161, 1995.