Skip Navigation
ChemIDplus A TOXNET DATABASE Lite•Browse•Advanced

Substance Name: Fenfluramine hydrochloride [USAN]
RN: 404-82-0
UNII: 3KC089243P
InChIKey: ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Note

  • A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.

Molecular Formula

  • C12-H16-F3-N.Cl-H

Molecular Weight

  • 267.7203
 

Classification Codes

Classification Codes

  • Anorexic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule IV
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Fenfluramine hydrochloride [USAN]

MeSH Heading

  • Fenfluramin

Synonyms

  • (+-)-Fenfluramine
  • (+-)-Fenfluramine chloride
  • (+-)-Fenfluramine hydrochloride
  • 1-(3-Trifluoromethylphenyl)-2-ethylaminopropane hydrochloride
  • 1-(m-Trifluoromethylphenyl)-2-(ethylamino)propane hydrochloride
  • AHR 3002
  • AHR-3002
  • dl-Fenfluramine hydrochloride
  • EINECS 206-968-2
  • Fenfluramine HCl
  • Fenfluramine hydrochloride
  • Ganal
  • N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride (+-)-
  • N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine hydrochloride
  • N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride
  • Phenfluoramine hydrochloride
  • Ponderal
  • Ponderax
  • Pondimin
  • Racemic fenfluramine hydrochloride
  • UNII-3KC089243P
  • ZX008

Systematic Names

  • Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, hydrochloride
  • Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, hydrochloride, (+-)-
  • Fenfluramine hydrochloride
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-, hydrochloride
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-, hydrochloride, (+-)-

Superlist Names

  • DEA No. 1670
  • Fenfluramine
  • Ponderal
  • Pondimin

Registry Numbers

CAS Registry Number

  • 404-82-0

FDA UNII

  • 3KC089243P

Other Registry Number

  • 16105-77-4

Related Registry Number

  • 458-24-2 (Parent)

System Generated Number

  • 0000404820

Molecular Formulas

Molecular Formula

  • C12-H16-F3-N.Cl-H

Molecular Formula Fragments

  • C12-H16-F3-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChIKey

ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Smiles

Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 60mg/kg (60mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR		 Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
child LDLo oral 70mg/kg (70mg/kg) CARDIAC: OTHER CHANGES Clinical Toxicology. Vol. 14, Pg. 97, 1979.
dog LD50 intravenous 23mg/kg (23mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969.
dog LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR		 Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
guinea pig LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR		 Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
human TDLo oral 7mg/kg (7mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 British Medical Journal. Vol. 1, Pg. 740, 1967.
mouse LD50 intraperitoneal 92mg/kg (92mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)		 Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1561, 1978.
mouse LD50 intravenous 90mg/kg (90mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR		 Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
mouse LD50 oral 170mg/kg (170mg/kg)   Therapie. Vol. 20, Pg. 297, 1965.
rabbit LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY

BEHAVIORAL: TREMOR		 Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
rat LD50 intraperitoneal 90mg/kg (90mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY		 Toxicology and Applied Pharmacology. Vol. 19, Pg. 705, 1971.
rat LD50 oral 69mg/kg (69mg/kg) BEHAVIORAL: FLUID INTAKE Toxicology and Applied Pharmacology. Vol. 14, Pg. 182, 1969.
women TDLo oral 36mg/kg (36mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SLEEP

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE		 Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 161, 1995.