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Substance Name: Nidroxyzone [INN]
RN: 405-22-1
UNII: YN9DMN3CVQ
InChIKey: FJVAAURIDNIYAE-BJMVGYQFSA-N

Classification Codes

  • Chemotherapeutic
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C8-H10-N4-O5

Molecular Weight

  • 242.19
 
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Names and Synonyms

Name of Substance

  • Nidroxyzone
  • Nidroxyzone [INN]

Synonyms

  • 2-(3-Hydroxyethyl)-1-(5-nitrofurfuryliden)semicarbacid
  • 4-17-00-04471 (Beilstein Handbook Reference)
  • 5-Nitro-2-furaldehyde-2-(2-hydroxyethyl)semicarbazone
  • AI3-26827
  • BRN 0269535
  • EINECS 206-970-3
  • F-26 (VAN)
  • Furadroxyl
  • Furadroxyl R
  • Furadroxyl R' NF67
  • Furaxolon
  • Hydrazinecarboxamide, 1-(2-hydroxyethyl)-2-((5-nitro-2-furanyl)methylene)-
  • NF-67
  • Nidroxizona
  • Nidroxizona [INN-Spanish]
  • Nidroxyzon
  • Nidroxyzone
  • Nidroxyzonum
  • Nidroxyzonum [INN-Latin]
  • Nitrofuroxizonum
  • NSC 6474
  • UNII-YN9DMN3CVQ
  • USAF EA-3

Systematic Names

  • 2-Furaldehyde, 5-nitro-, 2-(2-hydroxyethyl)semicarbazone
  • 5-Nitro-2-furaldehyde 2-(2-hydroxyethyl)semicarbazone
  • Hydrazinecarboxamide, 1-(2-hydroxyethyl)-2-((5-nitro-2-furanyl)methylene)-
  • Nidroxyzone

Registry Numbers

CAS Registry Number

  • 405-22-1

FDA UNII

  • YN9DMN3CVQ

System Generated Number

  • 0000405221

Structure Descriptors

InChI

1S/C8H10N4O5/c9-8(14)11(3-4-13)10-5-6-1-2-7(17-6)12(15)16/h1-2,5,13H,3-4H2,(H2,9,14)/b10-5+

InChIKey

FJVAAURIDNIYAE-BJMVGYQFSA-N

Smiles

c1(oc([N+](=O)[O-])cc1)\C=N\N(CCO)C(N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 600mg/kg (600mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 313, 1950.
mouse LDLo unreported 300mg/kg (300mg/kg)   Antibiotics and Chemotherapy Vol. 3, Pg. 429, 1953.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 214 deg C   EXP
log P (octanol-water) -0.540 (none)   EST
Water Solubility 500 mg/L   EXP
Atmospheric OH Rate Constant 2.48E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.