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Substance Name: Fluproquazone [USAN:INN:BAN]
RN: 40507-23-1
UNII: U4K85O58HD
InChIKey: ZWOUXWWGKJBAHQ-UHFFFAOYSA-N

Molecular Formula

  • C18-H17-F-N2-O

Molecular Weight

  • 296.343
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Fluproquazone
  • Fluproquazone [USAN:INN:BAN]

Synonyms

  • 1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone
  • 4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone
  • 4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone
  • 4-Fluorphenyl-1-isopropyl-7-methyl-2(1H)-chinazolinon
  • 4-Fluorphenyl-1-isopropyl-7-methyl-2(1H)-chinazolinon [German]
  • 46-790
  • 5-24-04-00375 (Beilstein Handbook Reference)
  • BRN 0891838
  • Fluproquazona
  • Fluproquazona [INN-Spanish]
  • Fluproquazone
  • Fluproquazonum
  • Fluproquazonum [INN-Latin]
  • RF 46-790
  • SaH 46-790
  • Tormosyl
  • UNII-U4K85O58HD

Systematic Names

  • 2(1H)-Quinazolinone, 4-(4-fluorophenyl)-7-methyl-1-(1-methylethyl)-
  • 2(1H)-Quinazolinone, 4-(p-fluorophenyl)-1-isopropyl-7-methyl-
  • 4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone

Registry Numbers

CAS Registry Number

  • 40507-23-1

FDA UNII

  • U4K85O58HD

System Generated Number

  • 0040507231

Structure Descriptors

InChI

1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3

InChIKey

ZWOUXWWGKJBAHQ-UHFFFAOYSA-N

Smiles

c12c(c(c3ccc(F)cc3)nc(n1C(C)C)=O)ccc(c2)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 650mg/kg (650mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: GENERAL ANESTHETIC
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 879, 1984.
mouse LD50 oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 882, 1981.
rabbit LD50 oral 742mg/kg (742mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 882, 1981.
rat LD50 oral > 3gm/kg (3000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 882, 1981.