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Substance Name: Doxefazepam [INN]
RN: 40762-15-0
UNII: 231RV72C8L
InChIKey: VOJLELRQLPENHL-UHFFFAOYSA-N

Molecular Formula

  • C17-H14-Cl-F-N2-O3

Molecular Weight

  • 348.7596
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Name of Substance

  • Doxefazepam
  • Doxefazepam [INN]

Synonyms

  • 5-25-02-00247 (Beilstein Handbook Reference)
  • BRN 0767530
  • CCRIS 3705
  • Doxans
  • Doxefazepam
  • Doxefazepamum
  • Doxefazepamum [INN-Latin]
  • N-1-Hydroxyethyl-3-hydroxyflurazepam
  • SAS 643
  • UNII-231RV72C8L

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-
  • 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-3-hydroxy-1-(2-hydroxyethyl)-2H-1,4-benzodiazepin-2-one
  • Doxefazepam

Superlist Name

  • Doxefazepam

Registry Numbers

CAS Registry Number

  • 40762-15-0

FDA UNII

  • 231RV72C8L

System Generated Number

  • 0040762150

Structure Descriptors

InChI

1S/C17H14ClFN2O3/c18-10-5-6-14-12(9-10)15(11-3-1-2-4-13(11)19)20-16(23)17(24)21(14)7-8-22/h1-6,9,16,22-23H,7-8H2

InChIKey

VOJLELRQLPENHL-UHFFFAOYSA-N

Smiles

c12C(=NC(C(=O)N(c1ccc(c2)Cl)CCO)O)c1c(cccc1)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal > 1gm/kg (1000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 480, 1989.
dog LD50 oral > 2gm/kg (2000mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 480, 1989.
human TDLo unreported 71ug/kg (0.071mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Drugs of the Future. Vol. 3, Pg. 145, 1978.
mouse LD50 intraperitoneal 746mg/kg (746mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 480, 1989.
mouse LD50 oral > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 480, 1989.
rat LD50 intraperitoneal 544mg/kg (544mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 39, Pg. 480, 1989.
rat LD50 oral 2550mg/kg (2550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1294, 1975.