Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Lorajmine hydrochloride [USAN]
RN: 40819-93-0
UNII: F8RIT10785
InChIKey: HNUSYDFQYYRIHJ-UUFOBPRJSA-N

Classification Codes

  • Cardiac Depressant (Anti-Arrhythmic)
  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H27-Cl-N2-O3.Cl-H

Molecular Weight

  • 439.3802
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Lorajmine hydrochloride
  • Lorajmine hydrochloride [USAN]

Synonyms

  • 17-Monochloroacetylajmaline hydrochloride
  • Ajmaline 17-(chloroacetate) monohydrochloride
  • Lorajmine HCl
  • Lorajmine hydrochloride
  • Nevergor
  • Ritmos elle
  • UNII-F8RIT10785
  • WIN 11831

Systematic Name

  • Ajmalan-17,21-diol, 17-(chloroacetate), monohydrochloride, (17R,21alpha)-

Registry Numbers

CAS Registry Number

  • 40819-93-0

FDA UNII

  • F8RIT10785

System Generated Number

  • 0040819930

Molecular Formulas

Molecular Formula

  • C22-H27-Cl-N2-O3.Cl-H

Molecular Formula Fragments

  • C22-H27-Cl-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H27ClN2O3.ClH/c1-3-11-12-8-15-19-22(13-6-4-5-7-14(13)24(19)2)9-16(25(15)21(11)27)18(12)20(22)28-17(26)10-23;/h4-7,11-12,15-16,18-21,27H,3,8-10H2,1-2H3;1H/t11-,12-,15-,16-,18-,19-,20+,21+,22+;/m0./s1

InChIKey

HNUSYDFQYYRIHJ-UUFOBPRJSA-N

Smiles

CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H]([C@H]2[C@H]5OC(=O)CCl)N3[C@@H]1O)c6ccccc6N4C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 600mg/kg (600mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
guinea pig LDLo intravenous 120mg/kg (120mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
mouse LD50 intraperitoneal 176mg/kg (176mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: GENERAL ANESTHETIC
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
mouse LD50 intravenous 56100ug/kg (56.1mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: GENERAL ANESTHETIC
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
mouse LD50 oral 370mg/kg (370mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: GENERAL ANESTHETIC
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rabbit LDLo intravenous 67800ug/kg (67.8mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 intraperitoneal 139mg/kg (139mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: AGGRESSION
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 intravenous 17300ug/kg (17.3mg/kg) BEHAVIORAL: AGGRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 oral 480mg/kg (480mg/kg) BEHAVIORAL: AGGRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.