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Substance Name: Enprofylline [USAN:INN]
RN: 41078-02-8
UNII: DT7DT5E518
InChIKey: SIQPXVQCUCHWDI-UHFFFAOYSA-N

Molecular Formula

  • C8-H10-N4-O2

Molecular Weight

  • 194.193
 

Classification Codes

  • Adenosine A2 Receptor Antagonists
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Asthmatic Agents
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Autonomic Agents
  • Bronchodilator
  • Bronchodilator Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Purinergic Agents
  • Purinergic Antagonists
  • Purinergic P1 Receptor Antagonists
  • Respiratory System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Enprofylline
  • Enprofylline [USAN:INN]

Synonyms

  • 3,7-Dihydro-3-propyl-1H-purine-2,6-dione
  • 3-Propylxanthine
  • D 4028
  • D-4028
  • EINECS 255-201-8
  • Enprofilina
  • Enprofilina [INN-Spanish]
  • Enprofylline
  • Enprofyllinum
  • Enprofyllinum [INN-Latin]
  • Nilyph
  • Oxeze
  • UNII-DT7DT5E518

Systematic Names

  • 1H-Purine-2,6-dione, 3,7-dihydro-3-propyl-
  • Enprofylline

Registry Numbers

CAS Registry Number

  • 41078-02-8

FDA UNII

  • DT7DT5E518

System Generated Number

  • 0041078028

Structure Descriptors

InChI

1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)

InChIKey

SIQPXVQCUCHWDI-UHFFFAOYSA-N

Smiles

c12c(c([nH]c(n1CCC)=O)=O)[nH]cn2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 157mg/kg (157mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Acta Pharmacologica et Toxicologica. Vol. 49, Pg. 313, 1981.
mouse LD50 oral 254mg/kg (254mg/kg)   Pharmacological Research Communications. Vol. 22(Suppl,
rat LD50 oral 481mg/kg (481mg/kg)   Pharmacological Research Communications. Vol. 22(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 287-289 deg C   EXP
log P (octanol-water) 0.33 (none)   EXP
Water Solubility 1200 mg/L 25 EST
Vapor Pressure 2.36E-11 mm Hg 25 EST
Henry's Law Constant 1.35E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.42E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.