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Substance Name: Ceftezole sodium
RN: 41136-22-5
UNII: 3NHZ4Y117H
InChIKey: UGUMHWUOXWFPFH-JHQAJZDGSA-M

Classification Codes

  • Antibiotics
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C13-H11-N8-O4-S3.Na

Molecular Weight

  • 462.4699
 
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Names and Synonyms

Results Name

  • Ceftezole sodium

Name of Substance

  • Ceftezole sodium [JAN]

Synonyms

  • Alomen
  • Ceftezole sodium
  • Celoslin
  • Falomesin
  • UNII-3NHZ4Y117H

Systematic Name

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-3-((1,3,4-thiadiazol-2-ylthio)methyl)-, monosodium salt, (6R-trans)-

Registry Numbers

CAS Registry Number

  • 41136-22-5

FDA UNII

  • 3NHZ4Y117H

Related Registry Number

  • 26973-24-0 (Parent)

System Generated Number

  • 0041136225

Molecular Formulas

Molecular Formula

  • C13-H11-N8-O4-S3.Na

Molecular Formula Fragments

  • C13-H11-N8-O4-S3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C13H12N8O4S3.Na/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13;/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25);/q;+1/p-1/t8-,11-;/m1./s1

InChIKey

UGUMHWUOXWFPFH-JHQAJZDGSA-M

Smiles

[Na+].[O-]C(=O)C1=C(CSc2nncs2)CS[C@@H]3[C@H](NC(=O)Cn4cnnn4)C(=O)N13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 4gm/kg (4000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 24, Pg. 671, 1976.
mouse LD50 intraperitoneal 8900mg/kg (8900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Chemotherapy Vol. 24, Pg. 671, 1976.
mouse LD50 intravenous 4700mg/kg (4700mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 24, Pg. 671, 1976.
mouse LD50 oral > 15gm/kg (15000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Chemotherapy Vol. 24, Pg. 671, 1976.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 24, Pg. 671, 1976.
rabbit LD50 intravenous > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Chemotherapy Vol. 24, Pg. 671, 1976.
rabbit LD50 subcutaneous > 7gm/kg (7000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Chemotherapy Vol. 24, Pg. 671, 1976.
rat LD50 intraperitoneal > 11520mg/kg (11520mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 24, Pg. 671, 1976.
rat LD50 intravenous 3800mg/kg (3800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 24, Pg. 671, 1976.
rat LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Chemotherapy Vol. 24, Pg. 671, 1976.
rat LD50 subcutaneous > 15gm/kg (15000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Chemotherapy Vol. 24, Pg. 671, 1976.