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Substance Name: Belinostat (Non-Stereospecific)
RN: 414864-00-9
InChIKey: NCNRHFGMJRPRSK-UHFFFAOYSA-N

Note

  • A hydroxamate-type inhibitor of histone deacetylase.

    The drug Belinostat is the E isomer at 866323-14-0

    NCI: A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. (NCI Thesaurus)

Molecular Formula

  • C15-H14-N2-O4-S

Molecular Weight

  • 318.3516
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Belinostat (Non-Stereospecific)
  • PXD 101

Synonyms

  • Beleodaq
  • Belinostat
  • N-Hydroxy-3-(3-(phenylsulfamoyl)phenyl)prop-2-enamide
  • PDX101
  • PX 105684
  • PXD-101
  • PXD101

Systematic Names

  • 2-Propenamide, N-hydroxy-3-(3-((phenylamino)sulfonyl)phenyl)-
  • N-Hydroxy-3-(3-(phenylsulfamoyl)phenyl)prop-2-enamide

Registry Numbers

CAS Registry Number

  • 414864-00-9

Related Registry Number

  • 866323-14-0 (E Isomer)

System Generated Number

  • 0414864009

Structure Descriptors

InChI

InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)

InChIKey

NCNRHFGMJRPRSK-UHFFFAOYSA-N

Smiles

ONC(=O)C=Cc1cccc(c1)S(=O)(=O)Nc2ccccc2