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Substance Name: Biriperone [INN]
RN: 41510-23-0
UNII: 5776HBV7UD
InChIKey: YCNCIZWAGQTWBI-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H26-F-N3-O

Molecular Weight

  • 391.487
 
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Names and Synonyms

Name of Substance

  • Biriperone [INN]
  • Centbutindole

Synonyms

  • (+-)-4'-Fluoro-4-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)butyrophenone
  • Biriperona
  • Biriperona [Spanish]
  • Biriperone
  • Biriperonum
  • Biriperonum [Latin]
  • Centbutindole
  • NSC 143691
  • UNII-5776HBV7UD

Systematic Names

  • (+-)-4'-Fluoro-4-(3,4,6,7,12,12a-hexahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2(1H)-yl)butyrophenone
  • Butyrophenone, 4'-fluoro-4-(1,2,3,4,6,7,12,12a-octahydropyrazino(1',2':1,6)pyrido(3,4-b)indol-2-yl)-

Registry Numbers

CAS Registry Number

  • 41510-23-0

FDA UNII

  • 5776HBV7UD

System Generated Number

  • 0041510230

Structure Descriptors

InChI

1S/C24H26FN3O/c25-18-9-7-17(8-10-18)24(29)6-3-11-27-12-13-28-16-23-21(14-19(28)15-27)20-4-1-2-5-22(20)26-23/h1-2,4-5,7-10,19,26H,3,6,11-16H2

InChIKey

YCNCIZWAGQTWBI-UHFFFAOYSA-N

Smiles

c12c3c(cccc3)[nH]c1C[N@@]1CC[N@@](CCCC(c3ccc(cc3)F)=O)C[C@@H]1C2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 180mg/kg (180mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 312, 1982.
rat LD50 oral 700mg/kg (700mg/kg)   Drugs of the Future. Vol. 3, Pg. 803, 1978.