Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Carboplatin [USAN:USP:INN:BAN:JAN]
RN: 41575-94-4
UNII: BG3F62OND5
InChIKey: OLESAACUTLOWQZ-UHFFFAOYSA-L

Note

  • An organoplatinum compound that possesses antineoplastic activity.

Molecular Formula

  • C6-H12-N2-O4-Pt

Molecular Weight

  • 373.2666
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Cross-Linking Reagents
  • Drug / Therapeutic Agent
  • Indicators and Reagents
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Carboplatin
  • Carboplatin [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Carboplatin

Synonyms

  • 1,1-Cyclobutanedicarboxylate diammine platinum(II)
  • Carboplatin
  • Carboplatine
  • Carboplatine [French]
  • Carboplatino
  • Carboplatino [Spanish]
  • Carboplatinum
  • Carboplatinum [Latin]
  • Cbdca
  • CCRIS 3404
  • cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
  • cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
  • Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
  • Diammine-1,1-cyclobutane dicarboxylate platinum II
  • EINECS 255-446-0
  • HSDB 6957
  • JM 8
  • JM-8
  • NSC 201345
  • NSC 241240
  • NSC-241240
  • Paraplatin
  • Platinum(II), (1,1-cyclobutanedicarboxylato)diammine-, cis-
  • UNII-BG3F62OND5

Systematic Names

  • Carboplatin
  • Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
  • Platinum, diammine(1,1-cyclobutanedi(carboxylato-kappaO)(2-))-, (SP-4-2)-
  • Platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)-
  • Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)

Superlist Name

  • Carboplatin

Registry Numbers

CAS Registry Number

  • 41575-94-4

FDA UNII

  • BG3F62OND5

Other Registry Number

  • 70903-55-8

System Generated Number

  • 0041575944

Structure Descriptors

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChIKey

OLESAACUTLOWQZ-UHFFFAOYSA-L

Smiles

C12(C(=O)O[Pt](OC1=O)([NH3])[NH3])CCC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 31200ug/kg (31.2mg/kg)   Drugs in Japan Vol. -, Pg. 288, 1990.
mammal (species unspecified) LD50 unreported 158mg/kg (158mg/kg)   Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 22, Pg. 56, 1987.
mouse LD50 intraperitoneal 118mg/kg (118mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 27, Pg. 611, 1992.
mouse LD50 intravenous 89360ug/kg (89.36mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 unreported 180mg/kg (180mg/kg)   Recent Results in Cancer Research. Vol. 48, Pg. 12, 1974.
rat LD50 intravenous 60900ug/kg (60.9mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
National Technical Information Service. Vol. PB288-374,
rat LD50 oral 343mg/kg (343mg/kg)   Drugs in Japan Vol. -, Pg. 288, 1990.
rat LD50 subcutaneous 72mg/kg (72mg/kg)   Drugs in Japan Vol. -, Pg. 288, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.460 (none)   EST
Atmospheric OH Rate Constant 1.19E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.