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Substance Name: Lenvatinib [USAN:INN]
RN: 417716-92-8
UNII: EE083865G2
InChIKey: WOSKHXYHFSIKNG-UHFFFAOYSA-N

Note

  • A protein kinase inhibitor.

    NCI: A synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. Lenvatinib mesylate blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. /Mesylate/ (NCI Thesaurus)

Molecular Formula

  • C21-H19-Cl-N4-O4

Molecular Weight

  • 426.8581
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Lenvatinib
  • Lenvatinib [USAN:INN]

Synonyms

  • E 7080
  • E7080
  • ER-203492-00
  • Lenvatinib
  • Lenvima
  • UNII-EE083865G2

Systematic Name

  • 6-Quinolinecarboxamide, 4-(3-chloro-4- (((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-

Registry Numbers

CAS Registry Number

  • 417716-92-8

FDA UNII

  • EE083865G2

Other Registry Number

  • 942407-57-0

System Generated Number

  • 0417716928

Structure Descriptors

InChI

1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)

InChIKey

WOSKHXYHFSIKNG-UHFFFAOYSA-N

Smiles

COc1cc2c(cc1C(=O)N)c(ccn2)Oc3ccc(c(c3)Cl)NC(=O)NC4CC4