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Substance Name: Bezafibrate [USAN:INN:BAN:JAN]
RN: 41859-67-0
UNII: Y9449Q51XH
InChIKey: IIBYAHWJQTYFKB-UHFFFAOYSA-N

Note

  • An antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW DENSITY LIPOPROTEINS and increases HIGH DENSITY LIPOPROTEINS.

Molecular Formula

  • C19-H20-Cl-N-O4

Molecular Weight

  • 361.823
 

Classification Codes

  • Antihyperlipoproteinemic
  • Antimetabolites
  • Drug / Therapeutic Agent
  • Human Data
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Bezafibrate
  • Bezafibrate [USAN:INN:BAN:JAN]

MeSH Heading

  • Bezafibrate

Synonyms

  • 2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
  • Azufibrat
  • Beza-Lande
  • Beza-Puren
  • Bezabeta
  • Bezacur
  • Bezafibrat
  • Bezafibrat PB
  • Bezafibrate
  • Bezafibrato
  • Bezafibrato [INN-Spanish]
  • Bezafibrato [Spanish]
  • Bezafibratum
  • Bezafibratum [INN-Latin]
  • Bezalip
  • Bezamerck
  • BF-759
  • BM 15.075
  • BM 15075
  • BM-15.075
  • BRN 4267656
  • CCRIS 9085
  • Cedur
  • Difaterol
  • Durabezur
  • EINECS 255-567-9
  • Eulitop
  • Lipox
  • LO 44
  • Propanoic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-
  • Reducterol
  • Regadrin B
  • Sklerofibrat
  • Solibay
  • UNII-Y9449Q51XH

Systematic Names

  • Bezafibrate
  • Propanoic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-
  • Propionic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl-

Registry Numbers

CAS Registry Number

  • 41859-67-0

FDA UNII

  • Y9449Q51XH

System Generated Number

  • 0041859670

Structure Descriptors

InChI

1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)

InChIKey

IIBYAHWJQTYFKB-UHFFFAOYSA-N

Smiles

c1(C(NCCc2ccc(OC(C(O)=O)(C)C)cc2)=O)ccc(Cl)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 514mg/kg/60D- (514mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE British Medical Journal. Vol. 309, Pg. 929, 1994.
man TDLo oral 1326mg/kg/37W (1326mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Lancet. Vol. 341, Pg. 371, 1993.
monkey LDLo oral 2gm/kg (2000mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

GASTROINTESTINAL: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4337, 1988.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Medicamentos de Actualidad. Vol. 15, Pg. 215, 1979.
mouse LD50 oral 723mg/kg (723mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4293, 1988.
mouse LD50 subcutaneous 1635mg/kg (1635mg/kg)   Drugs in Japan Vol. -, Pg. 1226, 1995.
rat LD50 intraperitoneal 505mg/kg (505mg/kg)   Medicamentos de Actualidad. Vol. 15, Pg. 215, 1979.
rat LD50 oral 1082mg/kg (1082mg/kg) GASTROINTESTINAL: TUMORS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4293, 1988.
rat LD50 subcutaneous 1580mg/kg (1580mg/kg) GASTROINTESTINAL: TUMORS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 4293, 1988.
women TDLo oral 12mg/kg/18D-I (12mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS

BEHAVIORAL: COMA
American Journal of Gastroenterology. Vol. 94, Pg. 3626, 1999.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 186 deg C   EXP
log P (octanol-water) 4.250 (none)   EST
Atmospheric OH Rate Constant 4.03E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.