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Substance Name: ID 4708
RN: 42048-72-6
InChIKey: SBAFWLYMAPHVMW-UHFFFAOYSA-N

Note

  • Potent neuroleptic butyrophenone deriv with few side effects.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H24-F4-N2-O2

Molecular Weight

  • 424.4356
 
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Names and Synonyms

Name of Substance

  • ID 4708

Synonyms

  • 1-(3-(2-Amino-4-fluorobenzoyl)propyl)-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine
  • ID-4708

Systematic Names

  • 1-(2-Amino-4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-1-butanone, monohydrochloride
  • 1-Butanone, 1-(2-amino-4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-

Registry Numbers

CAS Registry Number

  • 42048-72-6

System Generated Number

  • 0042048726

Structure Descriptors

InChI

1S/C22H24F4N2O2/c23-17-6-7-18(19(27)14-17)20(29)5-2-10-28-11-8-21(30,9-12-28)15-3-1-4-16(13-15)22(24,25)26/h1,3-4,6-7,13-14,30H,2,5,8-12,27H2

InChIKey

SBAFWLYMAPHVMW-UHFFFAOYSA-N

Smiles

c1cc(cc(c1)C(F)(F)F)C2(CCN(CC2)CCCC(=O)c3ccc(cc3N)F)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 780mg/kg (780mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse LD50 subcutaneous 340mg/kg (340mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.