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Substance Name: Pumitepa [INN]
RN: 42061-52-9
UNII: 7AYY495RE0
InChIKey: KAEVHZSIYLATMK-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C12-H19-N8-O-P

Molecular Weight

  • 322.311
 
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Names and Synonyms

Name of Substance

  • Pumitepa
  • Pumitepa [INN]

Synonyms

  • 2-Dimethylamino-6-diethylenimidophosphamido-7-methylpurine
  • 2-Dimethylamino-6-diethyleniminophosphamido-7-methylpurine
  • BRN 1036986
  • Fopurin
  • Fopurine
  • P,P-Bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7H-purin-6-yl)phosphinic amide
  • P,P-Bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methylpurin-6-yl)phosphinic amide
  • Phopurine
  • Phopurinum
  • Pumitepa
  • Pumitepum
  • Pumitepum [Latin]
  • UNII-7AYY495RE0

Systematic Names

  • P,P-Bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methylpurin-6-yl)phosphinic amide
  • Phosphinic amide, P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7H-purin-6-yl)-

Registry Numbers

CAS Registry Number

  • 42061-52-9

FDA UNII

  • 7AYY495RE0

System Generated Number

  • 0042061529

Structure Descriptors

InChI

1S/C12H19N8OP/c1-17(2)12-14-10-9(18(3)8-13-10)11(15-12)16-22(21,19-4-5-19)20-6-7-20/h8H,4-7H2,1-3H3,(H,14,15,16,21)

InChIKey

KAEVHZSIYLATMK-UHFFFAOYSA-N

Smiles

n1c2c(n(c1)C)c(NP(=O)(N1CC1)N1CC1)nc(N(C)C)n2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 280mg/kg (280mg/kg)   Pharmaceutical Chemistry Journal Vol. 14, Pg. 363, 1980.
mouse LD50 intravenous 280mg/kg (280mg/kg)   Drugs of the Future. Vol. 8, Pg. 132, 1983.
rabbit LDLo intravenous 150mg/kg (150mg/kg)   Drugs of the Future. Vol. 8, Pg. 132, 1983.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 2(5), Pg. 73, 1980.
rat LD50 intravenous 175mg/kg (175mg/kg)   Drugs of the Future. Vol. 8, Pg. 132, 1983.