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Substance Name: Oxilorphan [USAN:INN]
RN: 42281-59-4
UNII: 9Y9J2J74TO
InChIKey: STBZIDOIKQNFCQ-HSALFYBXSA-N

Classification Codes

  • Antagonist (to Narcotics)
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C20-H27-N-O2

Molecular Weight

  • 313.4383
 
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Names and Synonyms

Name of Substance

  • Oxilorphan
  • Oxilorphan [USAN:INN]

Synonyms

  • (-)-17-(Cyclopropylmethyl)morphinan-3,14-diol
  • (-)-17-Cyclopropylmethylmorphinan-3,4-diol
  • (-)-3,14-Dihydroxy-N-(cyclobutylmethyl)morphinan
  • (L)-BC-2605
  • Bristol laboratories BC 2605
  • EINECS 255-749-8
  • l-N-Cyclopropylmethyl-3,14-dihydroxymorphinan
  • levo-BC 2605
  • levo-BC-2605
  • Oxilorfano
  • Oxilorfano [INN-Spanish]
  • Oxilorphan
  • Oxilorphane
  • Oxilorphane [INN-French]
  • Oxilorphanum
  • Oxilorphanum [INN-Latin]
  • UNII-9Y9J2J74TO

Systematic Names

  • Morphinan-3,14-diol, 17-(cyclopropylmethyl)-
  • Oxilorphan

Registry Numbers

CAS Registry Number

  • 42281-59-4

FDA UNII

  • 9Y9J2J74TO

System Generated Number

  • 0042281594

Structure Descriptors

InChI

1S/C20H27NO2/c22-16-6-5-15-11-18-20(23)8-2-1-7-19(20,17(15)12-16)9-10-21(18)13-14-3-4-14/h5-6,12,14,18,22-23H,1-4,7-11,13H2/t18-,19+,20-/m1/s1

InChIKey

STBZIDOIKQNFCQ-HSALFYBXSA-N

Smiles

Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]5(CCCC[C@@]35O)c2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 14ug/kg (0.014mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Clinical Pharmacology. Vol. 16, Pg. 183, 1976.
human TDLo subcutaneous 26ug/kg (0.026mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Drugs of the Future. Vol. 2, Pg. 746, 1977.
mouse LD50 intravenous 32mg/kg (32mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 193, Pg. 23, 1975.
mouse LD50 subcutaneous 315mg/kg (315mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Pharmacology and Experimental Therapeutics. Vol. 193, Pg. 23, 1975.