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Substance Name: Diltiazem [INN:BAN]
RN: 42399-41-7
UNII: EE92BBP03H
InChIKey: HSUGRBWQSSZJOP-RTWAWAEBSA-N

Note

  • A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.

Molecular Formula

  • C22-H26-N2-O4-S

Molecular Weight

  • 414.5234
 

Classification Codes

  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Diltiazem
  • Diltiazem [INN:BAN]

MeSH Heading

  • Diltiazem

Synonyms

  • Acalix
  • Adizem
  • Anoheal
  • BRN 3573079
  • Cardil
  • Cardizem
  • Cardizem LA
  • CRD-401
  • d-cis-Diltiazem
  • Dilacor XR
  • Dilcontin
  • Dilren
  • Dilta-Hexal
  • Diltiazem
  • Diltiazemum
  • Diltiazemum [INN-Latin]
  • Dilticard
  • Dilzen
  • EINECS 255-796-4
  • Endrydil
  • HSDB 6528
  • Incoril AP
  • UNII-EE92BBP03H

Systematic Names

  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
  • Diltiazem

Registry Numbers

CAS Registry Number

  • 42399-41-7

FDA UNII

  • EE92BBP03H

System Generated Number

  • 0042399417

Structure Descriptors

InChI

1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1

InChIKey

HSUGRBWQSSZJOP-RTWAWAEBSA-N

Smiles

COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 68mg/kg (68mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

BEHAVIORAL: MUSCLE WEAKNESS

BLOOD: CHANGES IN PLATELET COUNT
Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 273, 1995.
mouse LD50 intravenous 61mg/kg (61mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991.
mouse LD50 oral 740mg/kg (740mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991.
mouse LDLo intraperitoneal 220mg/kg (220mg/kg)   Indian Journal of Experimental Biology. Vol. 34, Pg. 1194, 1996.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.790 (none)   EST
Water Solubility 465 mg/L 25 EXP
Atmospheric OH Rate Constant 1.80E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.