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Substance Name: Butorphanol [USAN:INN:BAN]
RN: 42408-82-2
UNII: QV897JC36D
InChIKey: IFKLAQQSCNILHL-QHAWAJNXSA-N

Note

  • A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.

Molecular Formula

  • C21-H29-N-O2

Molecular Weight

  • 327.4651
 

Classification Codes

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Opioid
  • Antitussive
  • Antitussive Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Narcotic Antagonists
  • Narcotics
  • Peripheral Nervous System Agents
  • Respiratory System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule IV

Names and Synonyms

Name of Substance

  • Butorphanol
  • Butorphanol [USAN:INN:BAN]

MeSH Heading

  • Butorphanol

Synonyms

  • (-)-17-(Cyclobutylmethyl)morphinan-3,14-diol
  • Butorfanol
  • Butorfanol [INN-Spanish]
  • Butorphanol
  • Butorphanolum
  • Butorphanolum [INN-Latin]
  • EINECS 255-808-8
  • l-BC 2627
  • levo-BC-2627
  • UNII-QV897JC36D

Systematic Names

  • Butorphanol
  • Morphinan-3,14-diol, 17-(cyclobutylmethyl)-

Superlist Names

  • Butorphanol
  • DEA No. 9720

Registry Numbers

CAS Registry Number

  • 42408-82-2

FDA UNII

  • QV897JC36D

System Generated Number

  • 0042408822

Structure Descriptors

InChI

1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1

InChIKey

IFKLAQQSCNILHL-QHAWAJNXSA-N

Smiles

Oc1ccc2C[C@H]3N(CC4CCC4)CC[C@@]5(CCCC[C@@]35O)c2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo intraspinal 35ug/kg (0.035mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: EXCITEMENT
Anesthesia and Analgesia Vol. 64, Pg. 452, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 216 deg C   EXP
log P (octanol-water) 3.680 (none)   EST
Atmospheric OH Rate Constant 2.15E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.