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Substance Name: Butorphanol [USAN:INN:BAN]
RN: 42408-82-2
UNII: QV897JC36D
InChIKey: IFKLAQQSCNILHL-QHAWAJNXSA-N
Note
- A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
Molecular Formula
- C21-H29-N-O2
Molecular Weight
- 327.4651
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Opioid
- Antitussive
- Antitussive Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Narcotic Antagonists
- Narcotics
- Peripheral Nervous System Agents
- Respiratory System Agents
- Sensory System Agents
Superlist Classification Code
- DEA Schedule IV
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NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
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Names and Synonyms
Name of Substance
- Butorphanol
- Butorphanol [USAN:INN:BAN]
MeSH Heading
- Butorphanol
Synonyms
- (-)-17-(Cyclobutylmethyl)morphinan-3,14-diol
- Butorfanol
- Butorfanol [INN-Spanish]
- Butorphanol
- Butorphanolum
- Butorphanolum [INN-Latin]
- EINECS 255-808-8
- l-BC 2627
- levo-BC-2627
- UNII-QV897JC36D
Systematic Names
- Butorphanol
- Morphinan-3,14-diol, 17-(cyclobutylmethyl)-
Superlist Names
- Butorphanol
- DEA No. 9720
Registry Numbers
CAS Registry Number
- 42408-82-2
FDA UNII
- QV897JC36D
System Generated Number
- 0042408822
Structure Descriptors
InChI
1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1InChIKey
IFKLAQQSCNILHL-QHAWAJNXSA-NSmiles
Oc1ccc2C[C@H]3N(CC4CCC4)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| women | TDLo | intraspinal | 35ug/kg (0.035mg/kg) | PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: EXCITEMENT | Anesthesia and Analgesia Vol. 64, Pg. 452, 1985. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 216 | deg C | EXP | |
| log P (octanol-water) | 3.680 | (none) | EST | |
| Atmospheric OH Rate Constant | 2.15E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.