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Substance Name: Hydrochlorothiazide hydrochloride
RN: 42461-28-9
UNII: 8ZJA0NWF31
InChIKey: HNLAFWZKHCUIMC-UHFFFAOYSA-N

Note

  • A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Molecular Formula

  • C7-H8-Cl-N3-O4-S2.x-Cl-H

Molecular Weight

  • 334.2031
 

Classification Codes

  • Action Diuretics
  • Antihypertensive Agents
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Names and Synonyms

Name of Substance

  • Hydrochlorothiazide hydrochloride

Synonyms

  • 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, hydrochloride
  • Hydrochlorothiazide HCl
  • UNII-8ZJA0NWF31

Systematic Name

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide, hydrochloride

Registry Numbers

CAS Registry Number

  • 42461-28-9

FDA UNII

  • 8ZJA0NWF31

System Generated Number

  • 0042461289

Molecular Formulas

Molecular Formula

  • C7-H8-Cl-N3-O4-S2.x-Cl-H

Molecular Formula Fragments

  • C7-H8-Cl-N3-O4-S2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C7H8ClN3O4S2.ClH/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-2,10-11H,3H2,(H2,9,12,13);1H

InChIKey

HNLAFWZKHCUIMC-UHFFFAOYSA-N

Smiles

c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2.Cl