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Substance Name: Semagacestat [USAN:INN]
RN: 425386-60-3
UNII: 3YN0602W4W
InChIKey: PKXWXXPNHIWQHW-RCBQFDQVSA-N

Note

  • A gamma-secretase inhibitor.

Classification Codes

  • Treatment of Alzheimer's
  • Treatment of Alzheimer's Disease

Molecular Formula

  • C19-H27-N3-O4

Molecular Weight

  • 361.4393
 
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Names and Synonyms

Name of Substance

  • Semagacestat [USAN:INN]

Synonyms

  • (2S)-2-Hydroxy-3-methyl-N-((2S)-1-(((1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl)amino)-1-oxopropan-2-yl)butanamide
  • (N)-((S)-2-Hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
  • LY450139
  • N2-((2S)-2-Hydroxy-3-methylbutanoyl)-N1-((1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl)-L-alaninamide
  • Semagacestat
  • UNII-3YN0602W4W

Systematic Name

  • Butanamide, 2-hydroxy-3-methyl-N-((1S)-1-methyl-2-oxo-2-(((1S)-2,3,4,5-tetrahydro-3- methyl-2-oxo-1H-3-benzazepin-1-yl)amino)ethyl)-, (2S)-

Registry Numbers

CAS Registry Number

  • 425386-60-3

FDA UNII

  • 3YN0602W4W

Other Registry Numbers

  • 1644443-23-1
  • 866488-53-1

System Generated Number

  • 0425386603

Structure Descriptors

InChI

1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1

InChIKey

PKXWXXPNHIWQHW-RCBQFDQVSA-N