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Substance Name: Carmetizide [INN]
RN: 42583-55-1
UNII: 8695816VMO
InChIKey: PFRBORHNFYMVOA-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C10-H12-Cl-N3-O6-S2

Molecular Weight

  • 369.8048
 
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Names and Synonyms

Name of Substance

  • Carmetizide [INN]

Synonyms

  • 6-Chloro-3-carbomethoxy-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • BRN 0715143
  • Carbomethoxythiazide
  • Carmetizida
  • Carmetizida [INN-Spanish]
  • Carmetizide
  • Carmetizidum
  • Carmetizidum [INN-Latin]
  • DU 5747
  • DU-5747
  • UNII-8695816VMO

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-3-carboxylic acid, 7-(aminosulfonyl)-6-chloro-3,4-dihydro-2-methyl-, methyl ester, 1,1-dioxide
  • Methyl 6-chloro-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine-3-carboxylate 1,1-dioxide

Registry Numbers

CAS Registry Number

  • 42583-55-1

FDA UNII

  • 8695816VMO

System Generated Number

  • 0042583551

Structure Descriptors

InChI

1S/C10H12ClN3O6S2/c1-14-9(10(15)20-2)13-6-3-5(11)7(21(12,16)17)4-8(6)22(14,18)19/h3-4,9,13H,1-2H3,(H2,12,16,17)

InChIKey

PFRBORHNFYMVOA-UHFFFAOYSA-N

Smiles

COC(=O)C1Nc2cc(Cl)c(cc2S(=O)(=O)N1C)S(=O)(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 231, 1973.
mouse LD oral > 10gm/kg (10000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 231, 1973.
mouse LD subcutaneous > 5gm/kg (5000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 231, 1973.
rat LD intraperitoneal > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 231, 1973.
rat LD oral > 10gm/kg (10000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 231, 1973.
rat LD subcutaneous > 5gm/kg (5000mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 231, 1973.