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Substance Name: Fluorometholone [USP:INN:BAN:JAN]
RN: 426-13-1
UNII: SV0CSG527L
InChIKey: FAOZLTXFLGPHNG-KNAQIMQKSA-N

Note

  • A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

Molecular Formula

  • C22-H29-F-O4

Molecular Weight

  • 376.4651
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Name of Substance

  • Fluorometholone
  • Fluorometholone [USP:INN:BAN:JAN]

MeSH Heading

  • Fluorometholone

Synonyms

  • 9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
  • 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
  • AI3-52813
  • Cortilet
  • Delmeson
  • EINECS 207-041-5
  • Flumetholon
  • Fluor-Op
  • Fluormetholone
  • Fluormetholonum
  • Fluorometholone
  • Fluorometholonum
  • Fluorometholonum [INN-Latin]
  • Fluorometolona
  • Fluorometolona [INN-Spanish]
  • Fluorometolone
  • Fluorometolone [DCIT]
  • Fml
  • FML Forte
  • FML Liquifilm
  • FML S.O.P.
  • NSC 33001
  • Oxylone
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl-
  • Trilcin
  • U 8614
  • UNII-SV0CSG527L

Systematic Names

  • Fluorometholone
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)

Mixture Names

  • FML-S Liquifilm
  • Neo-Oxylone

Registry Numbers

CAS Registry Number

  • 426-13-1

FDA UNII

  • SV0CSG527L

System Generated Number

  • 0000426131

Structure Descriptors

InChI

1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1

InChIKey

FAOZLTXFLGPHNG-KNAQIMQKSA-N

Smiles

C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD oral > 2gm/kg (2000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974.
rat LD subcutaneous > 2gm/kg (2000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974.
rat LD50 intraperitoneal 443mg/kg (443mg/kg)   Drugs in Japan Vol. -, Pg. 981, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 297 deg C   EXP
log P (octanol-water) 2 (none)   EXP
Water Solubility 30 mg/L 25 EXP
Vapor Pressure 1.16E-11 mm Hg 25 EST
Henry's Law Constant 4.59E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.52E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.