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Substance Name: Fluorometholone [USP:INN:BAN:JAN]
RN: 426-13-1
UNII: SV0CSG527L
InChIKey: FAOZLTXFLGPHNG-KNAQIMQKSA-N
Note
- A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Molecular Formula
- C22-H29-F-O4
Molecular Weight
- 376.4651
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- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Allergic Agents
- Anti-Inflammatory Agents
- Drug / Therapeutic Agent
- Glucocorticoid
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms
Name of Substance
- Fluorometholone
- Fluorometholone [USP:INN:BAN:JAN]
MeSH Heading
- Fluorometholone
Synonyms
- 9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
- 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
- AI3-52813
- Cortilet
- Delmeson
- EINECS 207-041-5
- Flumetholon
- Fluor-Op
- Fluormetholone
- Fluormetholonum
- Fluorometholone
- Fluorometholonum
- Fluorometholonum [INN-Latin]
- Fluorometolona
- Fluorometolona [INN-Spanish]
- Fluorometolone
- Fluorometolone [DCIT]
- Fml
- FML Forte
- FML Liquifilm
- FML S.O.P.
- NSC 33001
- Oxylone
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl-
- Trilcin
- U 8614
- UNII-SV0CSG527L
Systematic Names
- Fluorometholone
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Mixture Names
- FML-S Liquifilm
- Neo-Oxylone
Registry Numbers
CAS Registry Number
- 426-13-1
FDA UNII
- SV0CSG527L
System Generated Number
- 0000426131
Structure Descriptors
InChI
InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1InChIKey
FAOZLTXFLGPHNG-KNAQIMQKSA-NSmiles
C[C@H]1C[C@H]2[C@@H]3CC[C@](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD | oral | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974. | |
rat | LD | subcutaneous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974. | |
rat | LD50 | intraperitoneal | 443mg/kg (443mg/kg) | Drugs in Japan Vol. -, Pg. 981, 1990. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 297 | deg C | EXP | |
log P (octanol-water) | 2 | (none) | EXP | |
Water Solubility | 30 | mg/L | 25 | EXP |
Vapor Pressure | 1.16E-11 | mm Hg | 25 | EST |
Henry's Law Constant | 4.59E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.52E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.