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Substance Name: Rifamycin SV, 8-(piperidinomethyl)-
RN: 4267-47-4
InChIKey: XBZVGVKCHFRKIC-VKUQTSLNSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C43-H58-N2-O12

Molecular Weight

  • 794.933
 
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Names and Synonyms

Results Name

  • Rifamycin SV, 8-(piperidinomethyl)-

Synonyms

  • BRN 5418030
  • NCI 145-609
  • NSC 145609
  • PF-63
  • Rifamycin SV, 8-(piperidinomethyl)-

Systematic Name

  • 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy-8-(piperidinomethyl)-, 21-acetate

Registry Numbers

CAS Registry Number

  • 4267-47-4

System Generated Number

  • 0004267474

Structure Descriptors

InChI

1S/C43H58N2O12/c1-21-14-13-15-22(2)42(53)44-33-28(20-45-17-11-10-12-18-45)37(50)30-31(38(33)51)36(49)26(6)40-32(30)41(52)43(8,57-40)55-19-16-29(54-9)23(3)39(56-27(7)46)25(5)35(48)24(4)34(21)47/h13-16,19,21,23-25,29,34-35,39,47-51H,10-12,17-18,20H2,1-9H3,(H,44,53)/b14-13+,19-16+,22-15-

InChIKey

XBZVGVKCHFRKIC-VKUQTSLNSA-N

Smiles

c12c(c(O)c3c4c(c(c(O)c3c2O)C)O[C@@](C)(C4=O)OC=C[C@@H](OC)[C@@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)[C@@H](C)C=CC=C(C)C(N1)=O)OC(=O)C)CN1CCCCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1700mg/kg (1700mg/kg)   Chemotherapia. Vol. 12, Pg. 155, 1967.
mouse LD50 intravenous 183mg/kg (183mg/kg)   "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977Vol. -, Pg. 531, 1977.