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Substance Name: Cyproterone acetate [USAN:JAN]
RN: 427-51-0
UNII: 4KM2BN5JHF
InChIKey: UWFYSQMTEOIJJG-FDTZYFLXSA-N
Note
- An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
Molecular Formula
- C24-H29-Cl-O4
Molecular Weight
- 416.9421
Classification Codes
- Androgen Antagonists
- Anti-Androgen
- Antineoplastic Agents
- Contraceptive Agents
- Contraceptive Agents, Male
- Drug / Therapeutic Agent
- Hormone Antagonists
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
- Mutation Data
- Reproductive Control Agents
- Reproductive Effect
- Tumor Data
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Names and Synonyms
Name of Substance
- Cyproterone acetate
- Cyproterone acetate [USAN:JAN]
MeSH Heading
- Cyproterone acetate
Synonyms
- 1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate
- 1,2-alpha-Methylene-6-chloro-delta(sup 6)-17-alpha-hydroxyprogesterone acetate
- 1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate
- 17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione
- 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-
- 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
- 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat [German]
- 6-Chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup 6)-progesterone acetate
- 6-Chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesterone acetate
- 6-Chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione acetate
- 6-Chloro-1beta,2beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
- 6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate
- 6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate
- Androcur
- CCRIS 4385
- Cyprostat
- Cyproteron acetate
- Cyproteron-R acetate
- Cyproterone 17-O-acetate
- Cyproterone 17alpha-acetate
- Cyproterone acetate
- EINECS 207-048-3
- HSDB 3592
- NSC 81430
- NSC-81430
- Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-, acetate
- SH 714
- SH 80714
- UNII-4KM2BN5JHF
Systematic Names
- 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-
- 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate
- 6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate
- Cyproterone acetate
Superlist Name
- Cyproterone acetate
Registry Numbers
CAS Registry Number
- 427-51-0
FDA UNII
- 4KM2BN5JHF
System Generated Number
- 0000427510
Structure Descriptors
InChI
InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1InChIKey
UWFYSQMTEOIJJG-FDTZYFLXSA-NSmiles
CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | oral | 171mg/kg/17W- (171mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED | Israel Journal of Medical Sciences. Vol. 30, Pg. 238, 1994. |
man | TDLo | oral | 514mg/kg/7W-I (514mg/kg) | LIVER: LIVER FUNCTION TESTS IMPAIRED LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" | Australian and New Zealand Journal of Medicine. Vol. 26, Pg. 724, 1996. |
mouse | LD50 | intraperitoneal | 3300mg/kg (3300mg/kg) | Drugs in Japan Vol. 6, Pg. APP-4, 1982. | |
mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-4, 1982. | |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-4, 1982. | |
rat | LD50 | intraperitoneal | 565mg/kg (565mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982. | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-4, 1982. | |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-4, 1982. |