Substance Name: Certolizumab pegol [USAN:INN:BAN:JAN]
RN: 428863-50-7
Notes
- A PEGylated humanized anti-TNF fragment
- A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Molecular Formula
- Unspecified
Classification Codes
- Antirheumatic Agents
- Immunologic Factors
- Immunosuppressive Agents
- Treatment of Rheumatoid Arthritis and Inflammatory Bowel Disease, Specifically Crohn's Disease
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Certolizumab pegol
- Certolizumab pegol [USAN:INN:BAN:JAN]
MeSH Heading
- Certolizumab Pegol
Synonyms
- CDP 870
- CDP870
- Certolizumab
- Certolizumab pegol
- Cimzia
- CZP
- HSDB 7848
- PHA 738144
- PHA-738144
- UNII-G6ADW90R16
- UNII-UMD07X179E
Systematic Names
- Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated
- Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety)
Registry Numbers
CAS Registry Number
- 428863-50-7
FDA UNIIs
- G6ADW90R16
- UMD07X179E
Other Registry Numbers
- 1132819-27-2
- 339184-10-0
System Generated Number
- 0428863507