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Substance Name: Certolizumab pegol [USAN:INN:BAN:JAN]
RN: 428863-50-7

Notes

  • A PEGylated humanized anti-TNF fragment
  • A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antirheumatic Agents
  • Immunologic Factors
  • Immunosuppressive Agents
  • Treatment of Rheumatoid Arthritis and Inflammatory Bowel Disease, Specifically Crohn's Disease

Names and Synonyms

Name of Substance

  • Certolizumab pegol
  • Certolizumab pegol [USAN:INN:BAN:JAN]

MeSH Heading

  • Certolizumab Pegol

Synonyms

  • CDP 870
  • CDP870
  • Certolizumab
  • Certolizumab pegol
  • Cimzia
  • CZP
  • HSDB 7848
  • PHA 738144
  • PHA-738144
  • UNII-G6ADW90R16
  • UNII-UMD07X179E

Systematic Names

  • Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated
  • Immunoglobulin, anti-(human tumor necrosis factor alpha) Fab' fragment (human-mouse monoclonal CDP870 heavy chain), disulfide with human-mouse monoclonal CDP870 light chain, pegylated. Molecular weight is 47,696 daltons (unpegylated moiety)

Registry Numbers

CAS Registry Number

  • 428863-50-7

FDA UNIIs

  • G6ADW90R16
  • UMD07X179E

Other Registry Numbers

  • 1132819-27-2
  • 339184-10-0

System Generated Number

  • 0428863507