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Substance Name: Cladribine [USAN:USP:INN:BAN]
RN: 4291-63-8
UNII: 47M74X9YT5
InChIKey: PTOAARAWEBMLNO-KVQBGUIXSA-N

Note

  • An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.

Molecular Formula

  • C10-H12-Cl-N5-O3

Molecular Weight

  • 285.69
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Immunologic Factors
  • Immunosuppressive Agents
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Cladribine
  • Cladribine [USAN:USP:INN:BAN]

MeSH Heading

  • Cladribine

Synonyms

  • 2-CDA
  • 2-Chloro-2'-deoxy-beta-adenosine
  • 2-Chloro-2'-deoxyadenosine
  • 2-Chloro-6-amino-9-(2-deoxy-beta-D-erythropentofuranosyl)purine
  • 2-Chlorodeoxyadenosine
  • Adenosine, 2-chloro-2'-deoxy-
  • BRN 0624220
  • CCRIS 9374
  • Chlorodeoxyadenosine
  • Cladarabine
  • Cladribine
  • HSDB 7564
  • Leustatin
  • NSC 105014
  • NSC 105014-F
  • RWJ 26251
  • UNII-47M74X9YT5

Systematic Name

  • Adenosine, 2-chloro-2'-deoxy-

Superlist Name

  • Cladribine

Registry Numbers

CAS Registry Number

  • 4291-63-8

FDA UNII

  • 47M74X9YT5

Other Registry Number

  • 24757-90-2

System Generated Number

  • 0004291638

Structure Descriptors

InChI

1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChIKey

PTOAARAWEBMLNO-KVQBGUIXSA-N

Smiles

n1(c2c(c(nc(n2)Cl)N)nc1)[C@@H]1O[C@H](CO)[C@H](C1)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 700ug/kg/7D-C (0.7mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" American Journal of Hematology. Vol. 53, Pg. 209, 1996.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Leukemia and Lymphoma. Vol. 5, Pg. 1, 1991.