|
|
Substance Name: Cladribine [USAN:USP:INN:BAN]
RN: 4291-63-8
UNII: 47M74X9YT5
InChIKey: PTOAARAWEBMLNO-KVQBGUIXSA-N
Note
- An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Molecular Formula
- C10-H12-Cl-N5-O3
Molecular Weight
- 285.69
Classification Codes
- Antineoplastic
- Antineoplastic Agents
- Drug / Therapeutic Agent
- Human Data
- Immunologic Factors
- Immunosuppressive Agents
- Mutation Data
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Cladribine
- Cladribine [USAN:USP:INN:BAN]
MeSH Heading
- Cladribine
Synonyms
- 2-CDA
- 2-Chloro-2'-deoxy-beta-adenosine
- 2-Chloro-2'-deoxyadenosine
- 2-Chloro-6-amino-9-(2-deoxy-beta-D-erythropentofuranosyl)purine
- 2-Chlorodeoxyadenosine
- Adenosine, 2-chloro-2'-deoxy-
- BRN 0624220
- CCRIS 9374
- Chlorodeoxyadenosine
- Cladarabine
- Cladribine
- HSDB 7564
- Leustatin
- NSC 105014
- NSC 105014-F
- RWJ 26251
- UNII-47M74X9YT5
Systematic Name
- Adenosine, 2-chloro-2'-deoxy-
Superlist Name
- Cladribine
Registry Numbers
CAS Registry Number
- 4291-63-8
FDA UNII
- 47M74X9YT5
Other Registry Number
- 24757-90-2
System Generated Number
- 0004291638
Structure Descriptors
InChI
InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1InChIKey
PTOAARAWEBMLNO-KVQBGUIXSA-NSmiles
Nc1nc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | intravenous | 700ug/kg/7D-C (0.7mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | American Journal of Hematology. Vol. 53, Pg. 209, 1996. |
mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Leukemia and Lymphoma. Vol. 5, Pg. 1, 1991. |