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Substance Name: Levomethadyl acetate hydrochloride [USAN]
RN: 43033-72-3
UNII: B54CW5KG52
InChIKey: UXBPQRGCVJOTNT-COBSGTNCSA-N

Classification Codes

  • Analgesic (Narcotic)
  • Reproductive Effect
  • Tumor Data

Molecular Formula

  • C23-H31-N-O2.Cl-H

Molecular Weight

  • 389.964
 
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Names and Synonyms

Name of Substance

  • Levomethadyl acetate hydrochloride
  • Levomethadyl acetate hydrochloride [USAN]

Synonyms

  • (-)-(3S,6S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanol acetate (ester), hydrochloride
  • alpha-l-Acetylmethadol hydrochloride
  • Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester), hydrochloride, (S-(R*,R*))-
  • CCRIS 3321
  • l-Acetylmethadol hydrochloride
  • L-alpha-Acetylmethadol hydrochloride
  • LAAM
  • LAAM hydrochloride
  • LAAM-HCl
  • Levacetyl methadol hydrochloride
  • Levomethadyl acetate HCl
  • Levomethadyl acetate hydrochloride
  • MK 790
  • MK790
  • Orlaam
  • UNII-B54CW5KG52

Systematic Names

  • 3-Heptanol, 6-(dimethylamino)-4,4-diphenyl-, acetate (ester), hydrochloride, (3S,6S)-(-)-
  • Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester), hydrochloride, (S-(R*,R*))-
  • L-alpha-Acetylmethadol hydrochloride

Registry Numbers

CAS Registry Number

  • 43033-72-3

FDA UNII

  • B54CW5KG52

Other Registry Number

  • 5989-56-0

System Generated Number

  • 0043033723

Molecular Formulas

Molecular Formula

  • C23-H31-N-O2.Cl-H

Molecular Formula Fragments

  • C23-H31-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C23H31NO2.ClH/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21;/h7-16,18,22H,6,17H2,1-5H3;1H/t18-,22-;/m0./s1

InChIKey

UXBPQRGCVJOTNT-COBSGTNCSA-N

Smiles

Cl.CC[C@H](OC(=O)C)C(C[C@H](C)N(C)C)(c1ccccc1)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 71mg/kg (71mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Fundamental and Applied Toxicology. Vol. 11, Pg. 626, 1988.
mouse LD50 parenteral 11mg/kg (11mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 145, Pg. 11, 1964.
mouse LD50 subcutaneous 110mg/kg (110mg/kg)   Journal of Organic Chemistry. Vol. 17, Pg. 321, 1952.
rat LD50 oral 29mg/kg (29mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
JAT, Journal of Applied Toxicology. Vol. 14, Pg. 435, 1994.
rat LD50 subcutaneous 16mg/kg (16mg/kg)   JAT, Journal of Applied Toxicology. Vol. 14, Pg. 435, 1994.