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Substance Name: Amitriptylinoxide [INN]
RN: 4317-14-0
UNII: TYR2U59WMA
InChIKey: ZPMKQFOGINQDAM-UHFFFAOYSA-N

Classification Codes

  • Antidepressive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C20-H23-N-O

Molecular Weight

  • 293.4077
 
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Names and Synonyms

Name of Substance

  • Amitriptyline N-oxide
  • Amitriptylinoxide
  • Amitriptylinoxide [INN]

Synonyms

  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-N-oxide
  • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine N-oxide
  • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta5,gamma-propylamine-N-oxide
  • 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin N-oxid
  • Ambivalon
  • Amitriptilinoxido
  • Amitriptilinoxido [INN-Spanish]
  • Amitriptyline N-oxide
  • Amitriptylinoxide
  • Amitriptylinoxidum
  • Amitriptylinoxidum [INN-Latin]
  • Amitriptylinoxyde
  • Amitriptylinoxyde [INN-French]
  • BRN 2385442
  • Equilibrin
  • UNII-TYR2U59WMA

Systematic Names

  • 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine N-oxide
  • 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N,N-dimethyl-N-oxide

Registry Numbers

CAS Registry Number

  • 4317-14-0

FDA UNII

  • TYR2U59WMA

System Generated Number

  • 0004317140

Structure Descriptors

InChI

1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

InChIKey

ZPMKQFOGINQDAM-UHFFFAOYSA-N

Smiles

C1(\c2c(CCc3c1cccc3)cccc2)=C\CC[N+](C)(C)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 330mg/kg (330mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
guinea pig LD50 oral 330mg/kg (330mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
mouse LD50 intravenous 87mg/kg (87mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
mouse LD50 oral 330mg/kg (330mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
rabbit LD50 oral 330mg/kg (330mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
rat LD50 intraperitoneal 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
rat LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.
rat LD50 oral 1800mg/kg (1800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1898, 1978.